نتایج جستجو برای: stilbenes

تعداد نتایج: 1217  

Journal: :BMC Pharmacology 2008
Mark A Wilson Agnes M Rimando Catherine A Wolkow

BACKGROUND Stilbenes are 1,2-diphenylethylene congeners produced by plants in response to stress. Many stilbenes also exhibit xenobiotic activities in animal cells, such as inhibition of cancer cell growth, neuroprotection, and immune modulation. In vivo, hydroxylated stilbenes are metabolized by glucuronidation to facilitate excretion. Methoxylated stilbenes are metabolized more slowly, which ...

2013
Di Lu Wei Zhao Kuanpeng Zhu Shujin Zhao

Stilbenes are natural phenolic compounds which function as antimicrobial phytoalexins in plants and affect human health as cardioprotective, antibaceteria, antioxidative and antineoplastic agents. In this review, the progresses of study on relevant enzymes, genes, and regulation mechanism in biosynthesis pathway of stilbenes are described. Here we introduce a holistic and systematic method of r...

2007
Chul-Hee Cho Kwangyong Park

New unsymmetrical trans-stilbenes have been prepared by the sequential coupling reactions of bromobenzenesulfonate with formylarylboronic acids, benzylphosphonates and arylmagnesium bromides and characterized. The nickel-catalyzed reactions of stilbenesulfonates with aryl Grignard reagents produced the corresponding stilbenes via the nucleophilic aromatic substitution of the neopentyloxysulfony...

2012
Donato F. Romagnolo Cindy D. Davis John A. Milner

1. Abstract 2. Introduction 3. Phytoalexins and cancer prevention mechanisms 3.1. Antimicrobial activity 3.2. Proliferation 3.2.1. Cruciferous phytoalexins 3.2.2. Deoxyanthocyanidins 3.2.3. Glycoalkaloids 3.2.4. Stilbenes 3.2.5. Phenolic coumarins and garlic phytoalexins 3.3. Apoptosis 3.3.1. Stilbenes 3.3.2. Phenolic coumarins 3.3.3. Glycoalkaloids 3.3.4. Garlic phytoalexins 3.3.5. Di-terpenes...

Journal: :Natural product reports 2009
Tao Shen Xiao-Ning Wang Hong-Xiang Lou

Natural stilbenes have been a hot research topic due to their intricate structures and diverse biological activities. Although their molecular backbone consists only of 1,2-diphenylethylene units, stilbenes show an enormous diversity with regard to the different units present, the degree of polymerisation, and the pattern of oligomer construction. From January 1995 to the end of 2008, more than...

Journal: :Molecules 2016
Leo-Paul Tisserant Aziz Aziz Nathalie Jullian Philippe Jeandet Christophe Clément Eric Courot Michèle Boitel-Conti

Stilbenes are defense molecules produced by grapevine in response to stresses including various elicitors and signal molecules. Together with their prominent role in planta, stilbenes have been the center of much attention in recent decades due to their pharmaceutical properties. With the aim of setting up a cost-effective and high purity production of resveratrol derivatives, hairy root lines ...

Journal: :Anticancer research 2006
Malgorzata Bobrowska-Hägerstrand Magdalena Lillås Lucyna Mrówczyñska Anna Wróbel Yoshiaki Shirataki Noboru Motohashi Henry Hägerstrand

BACKGROUND Knowledge of the structure-activity relationships of multidrug resistance protein 1 (MRP1, ABCC1) inhibitors may aid in developing potent inhibitors that can be used to circumvent MRP1-mediated multidrug resistance. MATERIALS AND METHODS Six stilbenes were examined for their ability to inhibit MRP1-mediated transport of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from...

2016
J. Antoni Sirerol María L. Rodríguez Salvador Mena Miguel A. Asensi José M. Estrela Angel L. Ortega

Natural stilbenes are an important group of nonflavonoid phytochemicals of polyphenolic structure characterized by the presence of a 1,2-diphenylethylene nucleus. Stilbenes have an extraordinary potential for the prevention and treatment of different diseases, including cancer, due to their antioxidant, cell death activation, and anti-inflammatory properties which associate with low toxicity un...

2016
Hamza Temsamani Stéphanie Krisa Marion Decossas-Mendoza Olivier Lambert Jean-Michel Mérillon Tristan Richard

The aggregation of α-synuclein is one on the key pathogenic events in Parkinson's disease. In the present study, we investigated the inhibitory capacities of stilbenes against α-synuclein aggregation and toxicity. Thioflavin T fluorescence, transmission electronic microscopy, and SDS-PAGE analysis were performed to investigate the inhibitory effects of three stilbenes against α-synuclein aggreg...

Journal: :Natural product reports 2012
Céline Rivière Alison D Pawlus Jean-Michel Mérillon

Stilbenoids, a family of polyphenols known for the complexity of their structure and for their diverse biological activities, occur with a limited but heterogeneous distribution in the plant kingdom. The most prominent stilbene containing plant family, the Vitaceae, represented by the famous wine producing grape vines Vitis vinifera L., is one of the richest sources of novel stilbenes currently...

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