Abstract   Introduction: It is demonstrated that the degree of clinical improvement in   Parkinson's disease (PD) achieved by deep brain stimulation (DBS) is largely dependent   on the accuracy of lead placement. In addition, individual variability in the   situation of subthalamic nucleus (STN) is responsible for spatial inter-individual   fluctuations of the real patient's target.   Objecti...

background & aim: dbs (deep brain stimulation) is a new and successful technique in treatment of symptoms of parkinsonism especially after drug resistance. research in this field is mostly designed for evolution of this technique. the present study aimed at evaluating the relationship between the angle formed in midsagittal and stn (sub-thalamic nucleus) axis line and recording length in the fi...

abstract   introduction: it is demonstrated that the degree of clinical improvement in   parkinson's disease (pd) achieved by deep brain stimulation (dbs) is largely dependent   on the accuracy of lead placement. in addition, individual variability in the   situation of subthalamic nucleus (stn) is responsible for spatial inter-individual   fluctuations of the real patient's target.  ...

Sialyl Tn (sTn) is a mucin-associated carbohydrate antigen expressed in most types of human adenocarcinoma. Defining the configuration of tumor cell surface sTn recognized by antibodies is important for understanding the basis for the cancer cell specificity of sTn-reactive mAbs, for the development of more effective mAbs, and for designing cancer vaccines against sTn. In this study, we compare...

OBJECTIVE It has been suggested that abnormal synchronization and oscillation of neuronal activity in the subthalamic nucleus (STN) is associated with sensorimotor dysfunction in Parkinson's disease (PD). We investigated the bilateral subcortico-cortical functional coupling in PD patients. METHODS We simultaneously recorded local field potentials from the bilateral STN using electrodes insert...

The reciprocally connected GABAergic globus pallidus (GP)-glutamatergic subthalamic nucleus (STN) network is critical for voluntary movement and an important site of dysfunction in movement disorders such as Parkinson's disease. Although the GP is a key determinant of STN activity, correlated GP-STN activity is rare under normal conditions. Here we define fundamental features of the GP-STN conn...

Sialyl Tn (sTn) is a mucin-associated carbohydrate antigen expressed in most types of human adenocarcinoma. Defining the configuration of tumor cell surface sin recognized by antibodies is important for under standing the basis for the cancer cell specificity of sTn-reactive mAbs, for the development of more effective mAbs, and for designing cancer vac cines against sin. In this study, we compa...