Background: Parang Romang has an antihyperlipidemic effect, but the use of herbs limitations with poor solubility in water, causing failure clinical phase due to low bioavailability. Bioavailability can be increased nanotechnology, one which is nanoemulsion. Objectives: This study aimed determine pharmacokinetic profile and effectiveness from nanoemulsion preparation ethanol extract parang roma...

Background: Trigonella foenum-graecum Linn. (fenugreek) can ameliorate hyperglycemia and dyslipidemia, however, the detailed mechanism is unclear. The present study aims to investigate the effect of fenugreek seeds water extract (FSE) on 6-phosphofructo-1-kinase (PFK-1) activity, a key enzyme of glycolysis, in the liver and small intestine of streptozotocin induced diabetic rats and its impact ...

abstract background and objective: vascular abnormality and dysfunction plays an important role in the pathogenesis of vascular disease in diabetic state. in this study, we aimed to investigate whether an in vitro exposure of endothelium-intact aortic rings to melissa officinalis (lemon balm, mo) aqueous extract could have a beneficial effect in rats with subchronic diabetes. materials and meth...

background and objective: chronic diabetes mellitus (dm) leads to cardiovascular dysfunction. diosgenin is a natural steroidal saponin with cardiovascular protective potential. in this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats (n = 28) were d...

conclusions the administration of hydro-alcoholic leaf extract of c. colocynthis had a significant anti-hyperglycemic and anti hyperlipidemic effect and improved diabetic complications. in addition, citrullus c. leaf extract may have a protective effect on the liver, kidneys, and pancreas. results the results indicated that fasting blood sugar (fbs), triglycerides (tg), low-density lipoprotein ...

Nitric oxide plays a role in a series of neurobiological functions, underlying behaviour and memory. The functional role of nNOS derived nitric oxide in cognitive functions is elusive. The present study was designed to investigate the effect of specific neuronal nitric oxide synthase inhibitor, 7-nitroindazole, against intracerebroventricular streptozotocin-induced cognitive impairment in rats....