Diabetes mellitus is associated with many complications including retinopathy, nephropathy, neuropathy and angiopathy. Increased cardiovascular risk is accompanied with diabetes-induced endothelial dysfunction. Pharmacological agents with endothelium-protective effects may decrease cardiovascular complications. In present study sulodexide (glycosaminoglycans composed from heparin-like and derma...

PURPOSE To investigate in the kidney the pathologic changes and expression of GRP78 and CHOP in the Kunming (KM) mice with combination of high-fat diet and streptozotocin-induced diabetes. METHODS Sixty two male KM mice were randomly divided into a normal control (NC) group (n=20) and a high-fat diet (HFD) group (n=42). After a four-week dietary manipulation, the KM mice in the HFD group were...

The antibiotic streptozotocin [2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranoside], an analog of N-acetylglucosamine (NAG), has been shown to be useful for the selection of carbohydrate-negative and auxotrophic bacterial mutants. We have adapted this method for use with the oral pathogen Streptococcus mutans, a gram-positive, aerotolerant anaerobe that uses predominantly carbohydrates as ca...

Exogenous glucagon is known to increase hepatic lysosomes, but the relationships between endogenous glucagon and insulin levels and hepatic lysosomes have not been examined. To determine if the hormones of the pancreatic islets influence the development of these organelles glycogenosomes, dense bodies, and autophagosomes were morphometrically quantitated in normal rats, in rats with mild strept...

Background: Globally, medicinal plants are widely used to treat ailments due their safety, accessibility and efficacy. Objectives: The objective of this study was determine in vivo neuroprotective effect methanolic extract seeds Cydonia oblongaagainst streptozotocininduced diabetes rats, as research has not been reported previously. Methods: Methanolic (100, 150 200 mg/kg b.w) administered for ...

abstract diabetes is one of the most common metabolic diseases and in the long term affects many parts of body, including liver and kidneys. this study was to investigate alcoholic extract effect of alhagi camelorum on functional tests of liver and kidney in diabetic rats induced by streptozotocin. in this study, 28 wistar male rats were divided into the four groups (n = 7): non-diabetic contro...

Objectives: Diabetes is a complex chronic metabolic disorder. Today, many diabetes patients are known to supplement their standard therapies with herbal medications that have antidiabetic characteristics. The purpose of the study was examine fixed dose combination linagliptin and Emblica officinalis Gaertn (aq FE) for its hypoglycemic, hypolipidemic, antioxidant properties.
 Methods: Strep...

Introduction. There are evidence that oxidative stress is involved in the pathogenesis of acute generalized peritonitis and diabetes mellitus.The aim study was to examine levels products lipid peroxidation antioxidants rats with experimental against background streptozotocin-induced diabetes.Material methods. The experiment performed on 66 adult white male weighing 220-300 g. Diabetes mellitus ...