to 28 mM glucose. Concomitantly the SOD-specific activity (units of enzyme activity per milligram immunoreactive SOD) decreased 50% in alloxan-exposed islets. When islets were protected from alloxan toxicity by including 28 mM glucose with alloxan, the insulin secretory response and SOD specific activity remained identical to controls. Thus, SOD specific activity correlates with maintenance of ...

Streptozotocin is a natural product that selectively kills insulin-secreting beta cells, and is widely used to generate mouse models of diabetes or treat pancreatic tumors. Several studies suggest that streptozotocin toxicity stems from its N-nitrosourea moiety releasing nitric oxide and possessing DNA alkylating activity. However, it has also been proposed that streptozotocin induces apoptosis...

objective(s): this study was to investigate the potential anti-diabetic effects of alcoholic extract of salvia hydrangea in rats. materials and methods:thirty five male wistar rats were divided into five groups namely non-diabetic control, diabetic control, and three experimental diabetic that received either salvia hydrangea extract for 21 days at the doses of 100 and 200 or glibenclamide at t...

abstract  introduction: intracerebroventricular (icv) injection of streptozotocin (stz) causes cognitive impairment in rats. the beneficial effect of genistein (gen) was investigated on icv stz-induced learning, memory, and cognitive impairment in male rats. methods: for this purpose, rats were injected with icv stz bilaterally, on days 1 and 3 (3 mg/kg). the stz-injected rats received gen (1 m...

The alcoholic extract of Swertia chirayita was tested for its biochemical and pathomorphological effects in streptozotocin induced diabetes rats. Streptozotocin produced effectively all the animals at 45 mg/kg b.w. intraperitonially. diabetic showed significant increase serum levels glucose, cholesterol, triglycerides, ALT AST a reduction insulin levels. treated rats dose 500 b.w with improveme...

Assessing the Effects of Fullerene C60 on Markers Oxidative Stress in Testes Streptozotocin-Induced Diabetic Rats

Intracerebroventricular (i.c.v.) injection of streptozotocin has been introduced as a means to inhibit glucose utilization in the rat brain, and to induce changes in neurotransmitter systems and behavior which resemble those seen in Alzheimer's disease. In this study, enzyme activities previously investigated in Alzheimer's disease (peptidases, dehydrogenases and acetyltransferases) were measur...

retina is a part of the central nervous system derived from the neuroectoderm and made up of 5 layers.in this study, the changes in the thickness of the retinal layers as a consequence of diabetes and effect of aloe vera gel extract in male rats were assessed. thirty sprague dawley adult male rats (175 ± 25 g) in two age groups (4 and 8 weeks) were divided into 6 groups of 5 as control, diabeti...

objective(s): diabetes mellitus is a public health problem and one of the five leading causes of death globally. in the present study, the effect of metformin with natural honey was investigated on glycemia in the streptozotocin-induced diabetic rats. materials and methods: thirty wistar male rats were randomly divided into six groups including c: non ­diabetic rats received distilled water, ch...

The Effect of Melissa officinalis Extract on Streptozotocin-Induced Diabetes in Rats: A Stereological Study Pancreatic Islets and Beta-cells