Alloxan and streptozotocin are widely used to induce experimental diabetes in animals. The mechanism of their action in B cells of the pancreas has been intensively investigated and now is quite well understood. The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozot...

Diabetes mellitus (DM) is caused by either destruction of pancreatic β-cells (type 1 DM) or unresponsiveness to insulin (type 2 DM). Conventional therapies for diabetes mellitus have been developed but still needs improvement. Many diabetic patients have complemented conventional therapy with alternative methods including oral supplementation of natural products. In this study, we assessed whet...

In the present study, the effect of antioxidants-alpha lipoic acid, melatonin and trans resveratrol were studied against intracerebroventricular streptozotocin induced spatial memory deficit. Male Wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with alpha lipoic acid (200 mg/kg, po), melatonin (20 mg/kg, ip) and trans resverat...

Hypoglycemic effect of cyanobacteria has evaluated in the normal and streptozotocin-induced diabetic male albino rats as a mammalian model. Normal and streptozotocin-diabetic rats were orally administered cyanobacteria for 60 consecutive days, and their blood levels of glucose, insulin, C-peptide, lipid peroxidation, body weight and enzyme changes were determined using standard methods. Cyanoba...

S1 nuclease hydrolysis and hydroxyapatite chromatography were used to study the effect of the alkylating antibiotic, streptozotocin, on the secondary structure of DNA. Native calf thymus DNA was alkylated in vitro with increasing concentrations of streptozotocin and subjected to S1 nuclease hydrolysis. An increasing degree of DNA degradation was seen, suggesting a destabilization of the seconda...

Aim. To study the effect of eplerenone on activity free radical oxidation and renal function in rats with experimental diabetes mellitus induced by streptozotocin. Materials methods . Experiments were carried out 36 male Wistar rats. Diabetes (DM) was simulated a single intraperitoneal injection streptozotocin at dose 65 mg/kg. Eplerenone injected into stomach 50 Results. It found that diabetic...

Pain symptoms are a common complication of diabetic peripheral neuropathy or an inflammatory condition. In the most experiments, only one or two evident pain modalities are observed at diabetic peripheral neuropathy according to experimental conditions. Following diabetic peripheral neuropathy or inflammation, spinal glial activation may be considered as an important mediator in the development...

abstract objective: previous studies have indicated the hyperglycemia-induce cell death in various tissues such as brain, kidneys, liver and especially in the testis. recent studies have reported that diabetes can trigger male infertility. in this study we report the histological analysis of the testis tissue after diabetes type 1 induction in wistar rats. materials and methods: at various time...

The biological and metabolic effects of nitrosourea and its alkyl derivative Streptozotocin were compared and it was concluded that the two drugs have different modes of action. This conclusion is based on the following observa tions. Bacteria resistant to Streptozotocin are sensitive to all of the biological effects of nitrosomethylurea, i.e., devitalization, inhibition of cellular metabolism,...

measurement of serum creatinine (cr) and blood urea nitrogen (bun) are used as indicators of glomerular filtration rate. the increased levels of these biomarkers are usually detectable at advanced stages of kidney complications. the aim of this study was to find the interrelationship of beta-2 microglobulin (β2m), bun and cr in streptozotocin (stz)-induced diabetes mellitus in rabbits. diabetes...