objective: barberry root extract contains various alkaloids that are considered as antioxidants. beneficial effect of aqueous extract of berberis integerrima root (aebir) was evaluated for renal function in diabetic rats induced by stz. material and methods: diabetes was induced by i.p. injection of streptozotocin (65 mg/kg bw) to rats, after 15 h of fasting. diabetic rats were randomly grouped...

objective: frankincense improves memory in different models of learning. however, its influence on models of alzheimer's disease (ad) has not been studied widely. in the present study, the therapeutic effect of frankincense was evaluated in a model of ad induced by i.c.v administration of streptozotocin. materials and methods: under stereotaxic surgery, two guide cannulas were implanted in...

objectives: a wide range of liver and kidney disorders are associated with diabetes and there is a mutual relationship between diabetes and these diseases. herbal medicine with having abundant ingredients is one of these options. the goal of this study was to compare the effects of alcoholic extract of aerial parts of salvia hydrangea with glibenclamide on functional tests of liver and kidney i...

objective(s):the present study investigated the antidiabetic and hypolipidemic properties of dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. materials and methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of d.  aucheri (100, 200 and 400 mg/kg bw) or glibenclamide (0.25 mg/kg) f...

The effects on the pancreatic B cell of streptozotocin and its aglucone derivative N-nitrosomethylurea were investigated in obese-hyperglycaemic mice and their lean littermates. Both streptozotocin and N-nitrosomethylurea were found to be B-cytotoxic although N-nitrosomethylurea produced less islet damage. Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of...

Streptozotocin, an antibiotic widely used for induction of diabetes in experimental animals and for the treatment of pancreatic neoplasms, was shown to be a potent methylating agent reacting with DNA in vitro to form methylated purines. The reaction was similar in extent and relative proportions of methylation products to that produced by /V-methyl-N-nitrosourea, the aglycone of Streptozotocin....

Streptozotocin, which induces diabetes mellitus in experimental animals, has been reported to be taken up by beta-cells by means of the glucose transporter 2 (GLUT2) and then reduce the cellular level of NAD+, leading to necrosis of the beta-cells. We investigated the effect of insulin pretreatment on the diabetogenic action of streptozotocin (60 mg/kg). Four groups of rats were studied: 1) a g...

OBJECTIVES We investigated the effects of chronic (eight weeks) low-to moderate-intensity swimming training on thermal pain sensitivity in streptozotocin-induced diabetic female rats. METHODS Female Wistar rats (n = 51) were divided into the following groups: trained streptozotocin-induced diabetic rats [hyperglycemic trained (HT)], sedentary streptozotocin-induced diabetic rats [hyperglycemi...

Streptozotocin and alloxan were administered to Wistar rats in combination with poly(adenosine diphosphate ribose) synthetase inhibitors. Ten to 16 months after the injection of streptozotocin (50 mg/kg body weight i.v.) and 3-aminobenzamide (345 mg/kg i.v.), streptozotocin (50 mg/kg) and nicotinamide (350 mg/kg i.p.), streptozotocin (50 mg/kg) and picolinamide (250 mg/kg i.p.), alloxan (40 mg/...

These investigations delineate the recently described suppression of a form of cellular hypersensitivity in mice with streptozotocin-induced diabetes mellitus using a variety of cell-mediated immunologic responses in animals with several different forms of diabetes. Streptozotocin- and alloxan-induced diabetic mice and db/db genetically determined diabetic mice showed reductions in the areas of...