We investigate the role of M(2)-muscarinic receptors in maintaining neurogenic bladder contraction during hyperglycemia. Mice were injected with a single dose of streptozotocin (125 mg/kg), and neurogenic contraction of urinary bladder from wild type and M(2)-muscarinic receptor knockout (M(2) KO) mice was measured at 8 to 24 weeks after treatment. In wild-type bladder lacking urothelium, the s...

The mechanistic pathway for the antidiabetic efficacy of ethanolic extract of Punica granatum flowers (PgEFet) has been investigated by measuring the status of blood glucose, plasma insulin, carbohydrate metabolizing enzymes, lipid peroxidation and antioxidants as biochemical end points in streptozotocin induced diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of...

The present study was carried out to evaluate the antihyperglycemic property of Terminalia arjuna in streptozotocin-induced type 2 diabetic model rats. To and antioxidant role ethanol extract leaf Hyperglycemia induced rats by single intraperitoneal injection streptozotocin (STZ, 120mg/kg body weight). Three days after STZ induction, hyperglycemic were treated with a dilution bark T. orally at ...

We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role of NEP in neuropathy related to either insulin-deficient diabetes or diet-induced obesity using NEP deficient (-/-) mice. Initial studies showed that streptozotocin, in the abs...

Diabetes was induced in rats with Streptozotocin and alloxan and the tumorogenic effects of these two compounds were compared. One hundred thirty Lewis and SpragueDawley rats survived the induction of diabetes with Strepto zotocin. Fifty-six of these animals were sacrificed within 8 months of Streptozotocin administration and three were found to have renal tumors. Twenty-four of 74 (30.8%) Stre...

S, 'treptozotocin, an antibiotic produced from Streptomyces achromogenes, is now being used frequently for the production of experimental cataract." The exact mechanism of this cataract formation has not yet been determined. Streptozotocin has two distinct properties, either of which it was considered could be responsible for the cataract formation. First, Streptozotocin possesses the property ...

Diabetes merupakan penyakit kronis yang terjadi di saat insulin diproduksi oleh tubuh tidak bisa digunakan secara efektif maupun organ pankreas mengalami masalah dimana dapat sebagaimana mestinya. Kebaruan penelitian ini karena meneliti tentang efektivitas nanoherbal tomat (solanum lycopersicum) sebagai antihiperglikemia pada tikus diabetes terinduksi streptozotocin. Penelitian bertujuan untuk ...

statins have been reported to show preventive effect on nitrate tolerance in normal rats, but there are no reports on their effect in diabetic animals. in this study, diabetes was induced in male wistar rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). five groups of diabetic and five groups of normal rats were treated; groups 1 (of normal and diabetic rats) received ator...

the aqueous leaves extract of sesbania sesban (l) merr. (family: fabaceae) was evaluated for its antidiabetic potential on normal and streptozotocin (stz)-induced diabetic rats. in the chronic model, the aqueous extract was administered to normal and stz- induced diabetic rats at the doses of 250 and 500 mg/kg body weight (b.w.) p.o. per day for 30 days. the fasting blood glucose levels (bgl), ...

oxidative stress plays a major role in the pathogenesis of alzheimer's disease (ad) of sporadic origin. the expression of dhcr24 (seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of ad patients. in the present study, we investigated the effect of trimetazidine (tmz) on the hippocampal oxidative parameters and the expression of dhcr...