background the malonyl-coa decarboxylase (mcd, ec.4.1.1.9) enzyme regulates malonyl-coa levels. the effect of aerial parts extracts of urtica dioica (ud) on mcd is poorly understood. objectives the present experiment was undertaken to evaluate the effect of ud aerial parts extracts on mcd level. materials and methods in this experimental study, two groups of rats were used: normal and hyperglyc...

background and objective: based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid b on lessening of learning and memory deficits in streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats were allocated into control, salvialonic acid b-trea...

abstract  introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. with c onsidering the potential anti-diabetic effect of the medicinal plant withania somnifera (ws)( ashwagandha), this study was designed to investigate the analgesic effect of ws on formalin-induced nociceptive responses (standard formali...

The biochemical effect of S-1,3-butanediol on streptozotocin induced diabetic rats was studied. Rats were made diabetic by the intraperitoneal injection of 40 mg/kg body weight streptozotocin in sodium citrate buffer. A dosage of 25 mmol/kg body weight of S-1,3-butanediol was injected intraperitoneally for treatment. The streptozotocin induced diabetic rats showed a marked increase in blood glu...

Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism action antidiabetic agents. The aim work was comparative assessment manifestation hyperglycemia, DNA damage, and morphology internal organs in BALB/c mice modeling ...

Tephrosia purpurea has been reported to possess antidiabetic activity, however, its effects on cardiovascular complications and cataract associated with diabetes have not been studied. The objective of the present study was to investigate the effects of aqueous extract of Tephrosia purpurea on cardiovascular complications and cataract associated with streptozotocin-induced diabetes in rats. Spr...

objective(s) the present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme q10 (coq10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (icv-stz), an animal model of sporadic type of alzheimer's disease. materials and methods the lesion groups were injected bilaterally with icv-stz (1.5 mg/kg b.wt., in no...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

background: the memory impairment, obtained from intracerebroventricular (i.c.v.) infusion of streptozotocin (stz) in rats through activation of oxidative stress, is accepted as sporadic alzheimer’s disease (ad) model in most experimental studies. dimethyl sulfoxide (dmso) as a solvent is widely used in animal studies to have antioxidant effects as well. however, no report is available about dm...

Retinopathy leads to irreparable vision loss via capillary closure and areas of nonperfusion. However, the current instillation systems do not allow a sufficient amount of drug required to treat retinopathy to reach the posterior segment (retina); therefore, a new formulation targeting the posterior segment is expected as therapy for retinopathy. We prepared ophthalmic formulations containing n...