BACKGROUND Adenoid cystic carcinoma (ACC) is a subtype of malignant salivary gland tumors (MSGT), in which 90% of cases express cKIT. Dasatinib is a potent and selective inhibitor of five oncogenic protein tyrosine kinases (PTKs)/kinase families including cKIT. We conducted a phase II study to determine the antitumor activity of dasatinib in ACC and non-ACC MSGT. PATIENTS AND METHODS In a two...

BACKGROUND AND PURPOSE To investigate toxicity and efficacy in high-risk malignant salivary gland tumors (MSGT) of the head and neck. Local control in R2-resected adenoid cystic carcinoma was already improved with a combination of IMRT and carbon ion boost at only mild side-effects, hence this treatment was also offered to patients with MSGT and microscopic residual disease (R1) or perineural s...

In this paper, the free vibration analysis of sandwich micro beam with piezoelectric layers based on the modified couple stress and surface elasticity theories are investigated. The Hamilton’s principle is employed to derive the sandwich micro beam with piezoelectric based on modified couple stress theory incorporating with Gurtin- Murdoch surface theory. The generalized differential quadrature...

In this research, the surface stress effect on the nonlocal vibration of piezoelectric square plate reinforced by single walled carbon nanotubes (SWCNTs) based on classical plate theory (CPT) and first order shear deformation theory (FSDT) is presented. The elastic properties of piezoelectric nanocomposite plate are estimated by Eshelby-Mori-Tanaka and the extended mixture rule approaches. The ...

Shell-type nanostructures have recently attracted a lot of attention due to their several applications. The surface stress effect plays an important role in the mechanical behavior of such structures because of their large surface-to-volume ratio. In this paper, an analytical approach is presented for analyzing the geometrically nonlinear free vibrations of cylindrical nanoshells. In order ...