Finite element analysis of a tubular T-joint subjected to various loading conditions including pure axial loading, pure in-plane bending (IPB) and different ratios of axial loading to in-plane bending loading has been carried out. This effort has been established to estimate magnitudes of the peak hot spot stresses (HSS) at the brace/chord intersection and to find the corresponding locations as...

T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells. Pharmacological inhibition of cell stress reduces Th17 cell differentiation while stress inducers enhance the development of Th17 cells. The cellu...

The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions. The receptors binding APN to cardiac tissue, however, have remained elusive. Here, we report that the glycosyl phosphatidylinositol–anchored cell surface glycoprotein T-cadherin (encoded by Cdh13) protects against cardiac stress through its association with APN in mice. ...

Single-crystal magnesium micropillars (5 µm diameter) have been fabricated using focused ion beam (FIB) milling and loaded in compression along the [21¯1¯0] direction at cryogenic temperature (T = 184 K) three different strain rates: 10-4, 5 × 10-3 10-1 s-1. The stress-strain curves post-mortem analyses reveal predominance of {101¯2} twinning. critical stress required for twinning is detected t...

The role of stress in the pathophysiology of Graves' disease is suggested by several clinical observations, by recent advances in immunology and by better understanding of autoimmune diseases which provides new insights into potential effects of stress hormones on T helper cell imbalance involved in the pathogenesis of autoimmune diseases. Stress management should therefore be an important part...

Background: The fruit of Terminalia chebula (Combretaceae) has been used as traditional medicine against various human ailments, and has been extensively used in Ayurved, Uanai and Homeopathic medicine. The fruit was one of the Ayurvedic herbs used for the adaptogenic/anti-stress potential. The objective of the study was to investigate anti-stress activity of ethanolic extract of T. chebula fru...

The persistence of shear stress fluctuations in viscous liquids is a direct consequence of the non-zero shear stress of the local potential minima which couples stress relaxation to transitions between inherent structures. In simulations of 2D and 3D glass forming mixtures, we calculate the distribution of this inherent shear stress and demonstrate that the variance is independent of temperatur...

Reducing body temperature of rodents has been found to improve their survival to ischaemia, hypoxia, chemical toxicants, and many other types of insults. Larger species, including humans, may also benefit from a lower body temperature when recovering from CNS ischaemia and other traumatic insults. Rodents subjected to these insults undergo a regulated hypothermic response (that is, decrease in ...

Elastic wave velocity in a soft fiber that varies depending on material constitution and axial stress level is an essential measure of mechanical signals many technical applications. In this work, based the small-on-large theory, we establish model linear elastic propagation finitely pre-stretched fiber. The formulas longitudinal (L-) transverse (T-) velocities are provided validated by numeric...