TADB (http://bioinfo-mml.sjtu.edu.cn/TADB/) is an integrated database that provides comprehensive information about Type 2 toxin-antitoxin (TA) loci, genetic features that are richly distributed throughout bacterial and archaeal genomes. Two-gene and much less frequently three-gene Type 2 TA loci code for cognate partners that have been hypothesized or demonstrated to play key roles in stress r...

In order to reduce the noble metal palladium dosage in preparation of CL-20 so as its production cost, several carbon supports were prepared successfully using hydrothermal carbonization method absence or presence urea microcrystalline cellulose (MC) source, and corresponding Pd(OH)2/C catalysts fabricated deposition–precipitation method, which showed high activity debenzylation reaction hexabe...

Abstract We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T ligands) It catalogs 4,296 antigen variants 403 unique antigens 1500 ligands. also included neoantigens, class of generated through mutations resulting ...

TADB2.0 (http://bioinfo-mml.sjtu.edu.cn/TADB2/) is an updated database that provides comprehensive information about bacterial type II toxin-antitoxin (TA) loci. Compared with the previous version, the database refined and the new data schema is employed. With the aid of text mining and manual curation, it recorded 6193 type II TA loci in 870 replicons of bacteria and archaea, including 105 exp...

Persister cells are defi ned as a subpopulation of bacteria in dormant state with the ability to reduce bacterial metabolism and they involved antibiotic tolerance. Toxin-antitoxin (TA) systems have been previously suggested important players persistence. Therefore, this study aimed involvement TA persister cell formation methicillin-resistant Staphylococcus aureus following exposure. Using TAD...