The action mechanism for the production of spinal analgesia of KK-3, tyrosyl-N-methyl-gamma-aminobutylyl-phenylalaninol, was examined by the tail pinch and tail flick methods. Intrathecal KK-3, 2.5, 5 and 10 nmol/mouse, dose-dependently produced an analgesic effect in both methods. In the tail pinch method, the analgesia was suppressed by 2 mg/kg but not by 1 mg/kg of naloxone; however, the ana...

Purpose: To investigate the anti-inflammatory and analgesic activities of the Amorphophallus Bulbifer in Wistar rats and mice. Methods: The anti-inflammatory activity of the hydroalcohol extract of A. bulbifer whole plant at dose levels of 100 and 200 mg/kg p.o. in rats was determined with a plethysmograph paw volume difference of the animals preand post-treatment. Ibuprofen (10 mg/kg) was empl...

Prior work suggests that spinal systems are sensitive to the stimulus relationships that underlie Pavlovian conditioning. We studied this phenomenon in Sprague-Dawley rats by pairing a vibrotactile conditioned stimulus (CS) with a tailshock unconditioned stimulus (US). Experiment 1 showed that spinal rats exhibit differential conditioning, having longer tail-flick latencies on the tail-flick te...

Pain is relieved by analgesics that acts via modulating the central and peripheral pain mediators. Some of analgesic has been reported to have a serious adverse effects when used in long-term treatments. Therefore, there need developing potent with minimal no effects. In current study, quercetin chrysin were evaluated for activity mice rat hyperalgesia (Eddy’s hot plate Tail flick analgesiomete...

the antinociceptive effect of elaeagnus angustifolia fruits was studied in mice. the antinociceptive effect of ethanolic and boiling water extracts was studied using two thermal stimuli, the hot-plate and tail-flick tests. the intraperitoneal and oral administration of the ethanolic extract of seed 0.75-7.00 g/kg), but not pericarp and medulla had significant antinociceptive activity in the hot...

introduction: the antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. one of the major components of this pathway is the nucleus raphe magnus (nrm). our previous study demonstrated the involvement of nrm in the analgesic effect of morphine microinjected into the nucleus cuneiformis (ncf) in a descending manner. the aim of the current study wa...

background cisplatin is an effective antineoplastic drug used extensively in the treatment of malignancies. it induces painful peripheral neuropathy at high doses. objectives the aim of this study was to investigate the effect of carbamazepine (cbz) on cisplatin-induced peripheral neuropathic pain by using the tail-flick test. materials and methods the study was performed using male wistar rats...