Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate injected weekly) with or without resistance training (45 minutes three times we...

Testosterone glucuronide (unlabeled and labeled) was synthesized and injected into three normal men, one pregnant woman, and one child. In addition to testosterone glucuronide itself, several urinary metabolites were isolated. Only 5&androstane steroids were obtained. More 5/!Landrostane-3or, 17/3-diol than Sfl-androsterone was found. Meanwhile, a testosterone tracer gave Sa-metabolites, and mo...

objective (s): transdermal preparations for testosterone are becoming popular because of their unique advantages such as avoidance of first-pass effect, convenience, improved bioavailability, and reduction of systemic side effects. a novel testosterone transdermal delivery system (tdds) was developed using a palm oil base called hamintm (a commercial product) and tested using in vitro and in vi...

objective: the present study aimed to determine whether castration altered osmotically stimulated vasopressin (vp) release and urinary volume and what is the role of endocrine-stress axis in this process. materials and methods: totally 108 mice were studied in two main groups of castrated (n=78) and control (n=30). each group was extracted by acute cold stress (4◦c for 2h/day), restraint stress...

ObjectiveTo evaluate the effect of testosterone treatment on metabolic and inflammation parameters leukocyte-endothelium interactions in transgender men (TGM).DesignProspective observational study.SettingUniversity hospital.Patient(s)One hundred fifty-seven TGM.Intervention(s)Administration undecanoate (1,000 mg, intramuscular) every 12 weeks.Main Outcome Measure(s)Endocrine parameters, adhesio...

Background: Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Methods: Male adu...

Background: Recent studies reported lower androgen levels in coronavirus disease 2019 (COVID-19) hospitalized patients which linked to a worse prognosis. However, these were conducted with active and long-term consequences are still not yet known. Therefore, we aimed evaluate the late impact of COVID-19 pneumonia on testosterone recovered, post-hospitalized males. Methods: We enrolled 55 pneumo...

BACKGROUND Recent studies have shown that men with diabetes have lower testosterone levels than healthy men. However, studies on the correlation between testosterone and diabetes are rare in Korea. We examined the relationship between testosterone deficiency and markers related to diabetes in adult Korean men. METHODS A total 464 men with diabetes who visited an outpatient clinic at Ajou Univ...

Testosterone is typically understood to contribute to maleness and masculinity, although it also responds to behaviors such as competition. Competition is crucial to evolution and may increase testosterone but also is selectively discouraged for women and encouraged for men via gender norms. We conducted an experiment to test how gender norms might modulate testosterone as mediated by two possi...