Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats. Materials and Methods: ...

Background and Purpose: TGF-β is a potent regulator and suppressor of the immune system and overproduction of this cytokine may contribute to immunosuppression in HIV-infected patients. Increasing population of immunosuppressed patients has resulted in increasingly frequent of fungal infections, including oral candidiasis. The aim of this study was to evaluate the plasma levels of TGF-&bet...

Objective(s): Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 si...

Background: The production of recombinant proteins in Escherichia coli is one of the most valuable achievements in biotechnology, with many therapeutic and diagnostic applications; however, the aggregation and misfolding of proteins that result in the formation of insoluble inclusion bodies is a disruptive factor in this process. Various solubilization and refolding methods can be used to impro...

Chronic wounds affect more than 2% of the population worldwide, with a significant burden on affected individuals, healthcare systems, and societies. A key regulator entire wound healing cascade is transforming growth factor beta (TGF-β), which regulates not only inflammation extracellular matrix formation but also revascularization. This present work aimed at characterizing tissues obtained fr...

background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...