​Background and purpose: Glycation products, oxidative stress, and inflammation contribute to the development of diabetic nephropathy (DN) due to the elevation of transforming growth factor-β1 (TGF-β1). This study aimed at investigating the effect of Cysteine (Cys) on TGF-β in DN rat model. Materials and methods: In this experimental study, 40 male Wistar rats were randomly divided into four g...

BACKGROUND The role of transforming growth factor β1 (TGF-β1) and tumor necrosis factor α (TNF-α) in asthma is unclear. The aim of this study was to assess the relationships among polymorphisms, clinical phenotypes, and the serum levels of TGF-β1 and TNF-α. METHODS Polymorphisms of promoter of TGF-β1 (C-509T locus) and TNF-α (G-308 A locus; rs 1800629) in 217 asthmatic patients and 110 health...

Objective: This study’s aim was to assess the efficacy of topical Binahong (Anredera cordifolia (Ten.) Steenis) leaf ethanolic extract administration on serum transforming growth factor-beta 1 (TGF-β1) in infected wounds.
 Methods: An experimental study, vivo, conducted Biotechnology Laboratory and Animal House, Faculty Medicine, Universitas Sriwijaya, Palembang, from July September 2020. ...

Acute myeloid leukemia is a genetically heterogeneous clonal disease defined by the accumulation of immature cells in bone marrow and blood. The aim this study to evaluate CD33, CD11b, HLA-DR expression Iraqi AML patients its role evasion malignant from immune system. This was conducted on 60 with 20 healthy individuals as control group CD33 CD11b using flow-cytometry peripheral blood, Interfer...

Elevated levels of transforming growth factor-β1 (TGF-β1) and its positive correlation with Foxp3 expression in hepatitis E patients have indicated involvement of TGF-β1 in hepatitis E pathogenesis. The current study determined polymorphisms in TGF-β1 gene, plasma TGF-β1 levels and T effector (Teff) cell proliferation and explored their association in a case control study. Polymorphisms in thre...

To study the effects of transforming growth factor beta 1 (TGF-β1) on fibrosis and failure of regeneration of skeletal muscles, we generated a tet-repressible muscle-specific TGF-β1 transgenic mouse in which expression of TGF-β1 is controlled by oral doxycycline. The mice developed muscle weakness and atrophy after TGF-β1 over-expression. We defined the group of mice that showed phenotype withi...

Systemic sclerosis (SSc) is a connective tissue disorder representing fibrosis in the skin and internal organs such as lungs. An activated differentiation of local progenitor cells to myofibroblasts likely key mechanism underlying overproduction extracellular matrix resultant SSc. Calpains are family members Ca2+-dependent cysteine proteases for which biological action may contribute various or...

Background. Hepatitis B infection can lead to advanced liver disease (ALD) which causes serious health problems. Several factors that are thought play a role in P53, Transforming Growth Factor-β1 (TGF-β1), and Interleukin-10 (IL-10). Therefore, this study aimed determine the association between TGF-β1, IL-10 serum levels with ALD.Methods. We collected 68 sera from patients HBV infection. were m...

Liver fibrosis is characterized by changes in tissue architecture and extracellular matrix composition. Liver fibrosis affects not only hepatocytes but also the non-parenchymal cells such as hepatic stellate cells (HSCs), which are essential for maintaining an intact liver structure and function. Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that induces liver fibrosis th...