Vibrio parahaemolyticus has emerged as a major foodborne pathogen in China, Japan, Thailand, and other Asian countries. In this study, 72 strains of V. parahaemolyticus were isolated from clinical and environmental samples between 2006 and 2014 in Jiangsu, China. The serotypes and six virulence genes including thermostable direct hemolysin (TDR) and TDR-related hemolysin (TRH) genes were assess...

Background: Due to high genetic variation in human leukocyte antigen )HLA( alleles, epitope-based vaccines don’t show equal efficacy in different human populations. therefore, we proposed a multi-epitope vaccine against SARS-CoV-2 for Iranian populations. Materials and Methods: For this purpose, the proteins without allergenicity and high antigenicity as well as conservancy level from SARS-CoV...

background: re-emergence of pertussis has been reported in iran despite a high rate of vaccination coverage. low efficacy of the vaccine might be due to the genetic divergence between clinical versus vaccine strains. in the current study, the genetic profiles of clinical isolates and vaccine strains of bordetella pertussis (b. pertussis) were assessed by using pulsed field gel electrophoresis (...

We describe an efficient SCHEMA recombination-based approach for screening homologous enzymes to identify stabilizing amino acid sequence blocks. This approach has been used to generate active, thermostable cellobiohydrolase class I (CBH I) enzymes from the 390 625 possible chimeras that can be made by swapping eight blocks from five fungal homologs. Constructing and characterizing the parent e...

An influenza pandemic remains a major public health concern. A key strategy to prevent a pandemic is to stockpile and pre-position stable influenza vaccine to allow rapid deployment in response to an outbreak. However, most influenza vaccines today are formulated as liquids that are stable only within a temperature range of 2°C to 8°C and require use of a cold chain, making vaccine transportati...

Background: The arboviruses Zika virus (ZIKV) is a pathogen that threatens human health. Scientists have warned single mutation in the mosquito-borne ZIKV could spark another major outbreak of disease humans. Therefore, designing suitable vaccine for this seems necessary. This study aimed to predict protective epitopes envelope protein from with bioinformatics methods multi-epitope development....