The DAN/TIR genes of Saccharomyces cerevisiae encode homologous mannoproteins, some of which are essential for anaerobic growth. Expression of these genes is induced during anaerobiosis and in some cases during cold shock. We show that several heme-responsive mechanisms combine to regulate DAN/TIR gene expression. The first mechanism employs two repression factors, Mox1 and Mox2, and an activat...

BACKGROUND Infection with Escherichia coli O157:H7 rarely leads to bloody diarrhea and causes hemolytic uremic syndrome with renal failure that can be deadly dangerous. Intimin, translocated Intimin receptor (Tir), and enterohemorrhagic E. coli (EHEC) secreted protein A (EspA) proteins are the virulence factors expressed by locus of enterocyte effacement locus of EHEC. This bacterium needs EspA...

Introduction: The linear mixing of thermal infrared (TIR) emission spectra in multi-mineralic mixtures has been proven, and its limits and applicability have been quantitatively investigated [1,2]. Limiting factors in the accuracy of any linear retrieval (spectral deconvolution) algorithm include the spectral precision of the instrumentation as well as the fact that the number of end-members mu...

When enteropathogenic Escherichia coli (EPEC) attach and infect host cells, they induce a cytoskeletal rearrangement and the formation of cytoplasmic columns of actin filaments called pedestals. The attached EPEC and pedestals move over the surface of the host cell in an actin-dependent reaction [Sanger et al., 1996: Cell Motil Cytoskeleton 34:279-287]. The discovery that EPEC inserts the prote...

The tobacco N gene is a member of the Toll-interleukin-1 receptor/nucleotide-binding site/leucine-rich repeat (TIR-NBS-LRR) class of plant resistance (R) genes and confers resistance to tobacco mosaic virus (TMV). We investigated the importance of specific domains of N in inducing TMV resistance, by examining various N deletion and point mutations that introduce single amino acid substitution m...

over the last two decades there have been numerous reports from different seismically active regions of the world that thermal infrared (tir) anomalies can be identified around the epicentral areas before major earthquakes [e.g. (tronin et al., 2002)]. the tir anomalies reportedly appear as early as 14 to 7 days before the seismic events and affect areas as large as 1000s to 100,000s km2 in siz...

M any pathogenic bacteria modulate the host actin assembly machinery to promote infection and spread. Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a food-borne pathogen that causes severe diarrhea that can be accompanied by hemolytic uremic syndrome with potentially fatal consequences. Pathogenesis of EHEC and a closely-related pathogen, enteropathogenic E. coli (EPEC), is associated wi...

objective: escherichia coli (e.coli) o157:h7 is one of the most important pathogenic causes of hemorrhagic colitis in humans. cattle are the main reservoirs of this bacteria and vaccination is a key mechanism for its control. the intimin, translocated intimin receptor (tir), and espa proteins are virulence factors expressed by the lee locus of enterohemorrhagic e. coli. espa protein is a member...