breast cancer  patients  are  susceptible to  infections such  as  candidiasis. due  to  the importance and the role of matrix metalloproteinases (mmp) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of mmps -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in breast cancer bearing mice in the presence of systemic candida ...

background: considering the role of matrix metalloproteinase-3 (mmp-3) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) in the pathogenesis of periodontitis, the present study is to estimate the levels of mmp-3 and timp-1 in gingival crevicular fluid (gcf) in periodontal health, disease and to evaluate the effect of periodontal therapy on mmp-3 and timp-1 concentrations in gcf. mater...

the biological mechanisms of tooth movement are based on the response of periodontal tissues to mechanical forces. the final result of these responses is remodeling of the extracellular matrix. tissue reactions may vary depending upon the type, magnitude and duration of the applied forces. the purpose of the present study was to analyze the effects of centrifugal force on the transcription of c...

Introduction: Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting teeth and may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in gingival crevicular fluid chronic patients tissue inhibitor metalloproteinase-1 (TIMP‐1) an endogenous MMPs implicated inflammation. This review purpose discuss relationship betwe...

Periodontitis is typically associated with disorders characterized by compromised tooth-supporting tissue. Damage to periodontal tissue caused an imbalance between matrix metalloproteinases and their inhibitors. Decreased inhibitor elevated metalloproteinase levels result in collagen connective bone degradation. Several studies have shown that high of metalloproteinase-13 (MMP-13) low metallopr...

Objective(s): Osteoarthritis (OA), as a known degenerative joint disease, is the most common form of arthritis. In this study, we aimed to elucidate unclear pathogenesis of OA. Materials and Methods: Rabbit models of OA were established by the transection of the anterior cruciate ligament. Rabbits were randomly divided into three equal groups: the experimental group (OA modeling, treated with e...

BACKGROUND Matrix Metalloproteinase functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of the metalloproteinase family including the tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates the activity of multifunctional metalloproteina...

Pulmonary arterial hypertension (PAH) results from persistent vasoconstriction, smooth muscle growth and extracellular matrix (ECM) remodelling of pulmonary arteries (PAs). Matrix metalloproteinases (MMPs) are matrix-degrading enzymes involved in ECM turnover, and in smooth muscle cell (SMC) and endothelial cell migration and proliferation. MMP expression and activity are increased in experimen...

Tissue inhibitor of metalloproteinase 1 (TIMP1) controls matrix metalloproteinase activity through 1:1 stoichiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1 GPI) shifts the activity of TIMP-1 from the extracellular matrix to the cell surface. TIMP-1 GPI treated renal cell carcinoma cells show increased apoptosis and reduced proliferation. Transcriptom...

Background. Myocardial fibrosis is identified as a major side effect of Diabetes Mellitus on the heart. Some bio-markers including the ratio of matrix metalloproteinases and their inhibitors in collagen synthesis and collagen degradation are clinically useful in the diagnosis and identification of myocardial fibrosis. In addition, regular aerobic exercise training is one of the major and non-ph...