background celiac disease is an autoimmune mediated small intestine inflammation which is occurred due to hypersensitivity reaction to gluten and related proteins in diet in genetically predisposing individuals. prevalence of celiac among the population is about 0.5 – 1 % in most countries. frequency of celiac disease in children is a subject of few research .in this study, we aim to determine ...

the diagnosis of celiac disease (cd) relies on the concordance of pathological, serological, genetic and clinical features. for this reason, the diagnosis of cd is often a challenge. seronegative celiac disease (sncd) is defined by the negativity of anti-tissue transglutaminase antibodies in the presence of a positive histology on duodenal biopsy samples, i. e. inflammatory infiltrate of intra-...

abstract background and objective: celiac is an autoimmune disease that is characterized by an immune-system-related damage in the intestinal tissue after consumption of gluten. there is not any general agreement for gold standard. the purpose of this study was the evaluation of specificity and sensitivity of anti-endomysial (ema) and anti-tissue transglutaminase (ttg) serological test compared...

Tissue transglutaminase belongs to the multigene transglutaminase family of Ca2+-dependent protein cross-linking enzymes. Unlike other transglutaminases, it is involved in cell-matrix interactions and serves as an adhesion co-receptor for fibronectin. Previous work established that the fibronectin-binding motif(s) is located within the NH2-terminal proteolytic fragment of the protein consisting...

The present study examines the effects of water soluble extracts of gas-phase cigarette smoke on intracellular transglutaminase activities of intact, murine, bone marrow-derived macrophages maintained in culture. Western blotting of cell lysates utilizing noncross-reactive antisera indicate that mouse bone marrow-derived macrophages contain both tissue-type transglutaminase and factor XIII-asso...

Calcifying cartilages show a restricted expression of tissue transglutaminase. Immunostaining of newborn rat paw bones reveals expression only in the epiphyseal growth plate. Tissue transglutaminase appears first intracellularly in the proliferation/maturation zone and remains until calcification of the tissue in the lower hypertrophic zone. Externalization occurs before mineralization. Subsequ...

BACKGROUND With the appreciation of the high prevalence of coeliac disease there is increasing use of serology in screening asymptomatic people and testing those with suggestive features. AIM To compare the sensitivities and specificities of the endomysial antibody and the tissue transglutaminase antibody tests. METHODS Using electronic databases a search was made for relevant papers using ...

introduction: esophageal squamous-cell carcinoma (scc) is one of the most common malignancies in iran. to reduce the incidence of esophageal scc, it is important to recognize the controllable risk factors and prevent them. celiac disease is widely known as a possible risk factor for esophageal scc.  thus, we decided to assess the frequency of celiac disease in esophageal scc patients in north e...

background recent guidelines have proposed that there is a correlation between tissue transglutaminase (ttg) antibody titers and degrees of duodenal biopsy, and that duodenal biopsy can be omitted in some patients with high levels of ttg antibody. using data of registered patients in a gastrointestinal clinic we aimed to assess the correlation between tissue transglutaminase antibody with duode...