conclusions our results show a significant association of nos3 and mthfr gene polymorphisms with coronary atherosclerotic lesions. therefore, these variants might influence the risk of coronary artery disease, specifically in the iranian population. results we specifically detected the nos3 tt genotype in 12 patients (11.11%) and did not find the same genotype in any of the controls. the freque...

introduction: immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin b1 on the proinflammatory cytokines, edema, and...

Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned wit...

background: periodontitis and rheumatoid arthritis (ra) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (tnf-α)-induced bone resorption that is involved in the pathogenesis of both. objectives: to investigate the effect of tnf-α blockade on periodontal conditions in patients with active ra. method: the periodontal statuses of 3...

This study aims to investigate the effect of five-flavor sophora flavescens enteric-coated capsules (FSEC) on TNF-α-induced inflammatory bowel disease and its molecular mechanism. Wistar Rats were divided into 6 groups: Normal control group (group A): normal diet, drinking water; Model B): 100 μg/L TNF-α; FSEC high-dose C): 100μg/L TNF-α + (432 mg/kg); medium-dose D): (216 low-dose E): (108 Pos...

Background: Tumor necrosis factor- a (TNF-α) is a cytokine that was identified as a factor with a wide range of proinflammatory activities. The expression of bovine TNF-α in mammary tissue during pregnancy seems to have a role in development of the corresponding glands.Objective: Single nucleotide polymorphisms (SNPs) were defined in 3′-flanking region of...

dietary fatty acids play a critical role in modulation of airway inflammation in asthma. this study was conducted to compare dietary intakes of essential fatty acids and serum levels of inflammatory factors in asthmatic and healthy adults, and to examine the potential relationship between inflammatory markers and dietary fatty acids. in this case-control study, 47 asthmatic patients (26 males a...

objective(s): pulmonary fibrosis (pf) is the most common outcome of a collection of diverse lung disorders known as interstitial lung diseases. it is proposed that alterations in the levels of fibrogenic mediators and the profibrotic/antifibrotic imbalance play a substantial role in the progression of pf in animal models and possibly in humans. caffeic acid phenethyl ester (cape), an active com...