at present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but it’s optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one hundred patients adm...

at the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. in this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. one-hundred patients ...

OBJECTIVES This study was done to compare isoxpurine hydrochloride and nifedipine as tocolytic drugs for preterm labor. METHODS A prospective cohort study of 832 antenatal women with preterm labor was conducted in the Department of Obstetrics & Gynecology. Out of 400 women found eligible for tocolysis, 200 were given isoxpurine hydrochloride while the other 200 were given nifedipine randomly....

BACKGROUND Magnesium sulphate has been used in some settings as a tocolytic agent to inhibit uterine activity in women in preterm labour with the aim of preventing preterm birth. OBJECTIVES To assess the effects of magnesium sulphate therapy given to women in threatened preterm labour with the aim of preventing preterm birth and its sequelae. SEARCH METHODS We searched the Cochrane Pregnanc...

Background: Preterm birth continues to be a problem for obstetricians. complicates 8-10% of birth. Although the causes preterm labor are not well understood, burden is clear. Aim and objectives: The aim was study evaluate efficacy safety transdermal nitroglycerin as tocolytic agent in women with labor. Subjects methods: This prospective randomized controlled trial conducted obstetrics Gynecolog...

OBJECTIVE This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis. MATERIAL AND METHODS In total, 48 women between 27 and 34 weeks' gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 ...

OBJECTIVE To determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor. STUDY DESIGN A systematic review and metaanalysis of randomized controlled trials. RESULTS Twenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gest...

1. The influence of progesterone on the activity of atrial natriuretic factor (ANF) on rat myometrial motor activity was determined in vitro. 2. ANF inhibited the tension development by myometrium from cycling or oestrogen-treated rats in a dose-dependent manner; maximal inhibition was 100%. 3. Injections of progesterone into rats inhibited the tocolytic activity of ANF in a dose and time-depen...