PURPOSE Toxoplasma gondii is a widespread protozoan parasite that infects a broad range of warm blooded animals as well as humans. The present study was investigated to evaluate the effects of allium cepa on renal failur in male rats which experimentally infected by Toxoplasma gondii, RH strain. METHODS Wistar male rat (n=40) were allocated into four groups, group one that received tachyzoite...

Toxoplasma gondii is a zoonotic protozoa of economic significance in livestock. Infected livestock meat and products act as a source of T. gondii infection in humans. Current drugs against T. gondii are limited by hypersensitivity and toxicity, and are not effective against the encysted bradyzoite stage of T. gondii. Thus, there is urgent need for safe and effective therapeutic agents against T...

Toxoplasma gondii isolates can be grouped into 3 genetic lineages. Type I isolates are considered virulent to outbred mice, whereas Type II and III isolates are not. In the present report, viable T. gondii was isolated for the first time from striped skunk (Mephitis mephitis), Canada goose (Branta canadensis), and black-winged lory (Eos cyanogenia). For the isolation of T. gondii, tissues were ...

conclusions diabetes may be caused by toxoplasma gondii. presence of t. gondii in the pancreas at the same time could directly undermines the pancreas cells. when β cells are destroyed, insulin secretion would then be affected. probably the destruction of t. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes. results the prevalence of igg antibodies...

This study aimed to evaluate three sets of B1 gene DNA primer for the diagnosis Toxoplasma gondii. The gondii that stored on liquid nitrogen was isolated using DNAzol™ reagent. first step Polymerase Chain Reaction (PCRs) performed external and internal sets, respectively, then nPCR. PCR products sequencing by Apical Science. All sequences were analysed CLC Sequence Viewer Version 8.0 software c...

We report herein anti-proliferation effects of 4-arylthiosemicarbazides, with a cyclopentane substitution at N1 position, on highly virulent RH strain Toxoplasma gondii. Among them, the highest in vitro anti-Toxoplasma activity was found meta-iodo derivative. Further experiments demonstrated inhibitory thiosemicarbazides tyrosinase (Tyr) activity, and good correlation between percentage Tyr inh...

Cats are the definitive hosts of Toxoplasma gondii. Infected cats excrete oocysts in their feces, infecting humans and other animals. The objective of the present study was to determine the presence of anti-Toxoplasma antibodies in cat owners and their pets, and determine if there was a relationship between Toxoplasma infection and humans who live with infected cats. IgG anti-Toxoplasma antibod...

Variations in the prevalence of antibody to toxoplasma gondii is reported from various countries (Hong Kong 9.8%, London 22%, New York 30%, Paris 84%) and from various cities in the same country(Jeddah 32%, Abha 51%). An area densely populated with cats is believed to be heavily contaminated with toxoplasma oocysts, leading to an increasing infection. As MedinaMunawarah has a large number of ca...

Toxoplasma gondii is a unicellular parasite that causes severe brain and eye disease. Current drugs for T. gondii are limited by toxicity. Bumped kinase inhibitors (BKIs) selectively inhibit calcium-dependent protein kinases of the apicomplexan pathogens T. gondii, cryptosporidia, and plasmodia. A lead anti-Toxoplasma BKI, 1294, has been developed to be metabolically stable and orally bioavaila...