BACKGROUND Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Myrica sapida is known traditionally in ...

Carbocysteine is a mucoactive drug and is being used for both acute and chronic infectious airway diseases. Although carbocysteine can repair the damage of epithelial cells caused by exposure to various agents, the effects of this agent on allergic airway diseases such as asthma and eosinophilic bronchitis with an isolated chronic cough, in both of which epithelial damage may be characteristic,...

The underlying mechanism involved in the interaction between neutrophil elastase inhibitors and tachykinins has not been elucidated. In this study we have examined the effects of sivelestat, a neutrophil elastase inhibitor, on the in vitro responses of airways from lipopolysaccharide (LPS)-untreated or -treated guinea-pigs to substance P. Substance P (0.01-30 micromol/l) produced concentration-...

background:  assessment  of quality-of-life (qof) as  an outcome   measure   after  deep   brain  stimulation   (dbs) surgery in patients  with parkinson’s disease  (pd) need  a valid, reliable and responsive  instrument. the aim of the current   study   was   to   determine   responsiveness   of validated  persian  version  of pd questionnaire  with  39- items (pdq-39) after dbs surgery in pat...

background: hemodynamic instability is common during tracheal intubation. the primary purpose of the present study is to evaluate the effect of different doses of remifentanil added to propofol on the hemodynamic profiles during tracheal intubation. methods: ninety patients, 40 to 70 years old, undergoing coronary artery bypass graft surgery under general anesthesia were randomly allocated into...

admiration for environment in general needs to be profoundly rooted in an understanding of history. urban history is unique not only in the fact that it reflects climate but also in that it cuts across many different fields. in most schools of urban studies many aspects of science and technology are taught with relation to design in order to attain skills for practice. during a student’s later ...

The pulmonary disease of cystic fibrosis (CF) is characterized by persistent airway obstruction, which has been attributed to chronic endobronchial infection and inflammation. The levels of exhaled nitric oxide (NO) are reduced in CF patients, which could contribute to bronchial obstruction through dysregulated constriction of airway smooth muscle. Because airway epithelium from CF mice has bee...

Background: World Health Organization (WHO) defines three goals to assess the performance of a health system: the state of health, fairness in financial contribution and responsiveness. We assessed the responsiveness of health system for patients with diabetes in a defined population cohort in Tehran, Iran. Methods: Total responsiveness and eight domains (prompt attention, dignity, communica...

Background: World Health Organization (WHO) defines three goals to assess the performance of a health system: the state of health, fairness in financial contribution and responsiveness. We assessed the responsiveness of health system for patients with diabetes in a defined population cohort in Tehran, Iran. Methods: Total responsiveness and eight domains (prompt attention, dignity, communica...