two deoxyglucose (dg) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-d-glucose (ecb-dg) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-d-glucose (dhp-dg), were synthesized and radiolabeled successfully with [99mtc(h2o)3(co)3]+ complex. [99mtc]-ecb-dg and [99mtc]-dhp-dg complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mci of na99mtco4 in 1 ml saline. radi...

(99m)Tc tricarbonyl glycine monomers, trimers, and pentamers were synthesized and evaluated for their radiolabeling and in vivo distribution characteristics. We synthesized a (99m)Tc-tricarbonyl precursor with a low oxidation state (I). (99m)Tc(CO)3(H2O)3 (+) was then made to react with monomeric and oligomeric glycine for the development of bifunctional chelating sequences for biomolecules. La...

The carbene-C ,N chelate tetracarbonyl tungsten complex [(CO)4/ W C(Ph)NHC5H4N /-o ] (4), obtained from [(CO)5W / C(Ph)OMe] (3) and o -aminopyridine, reacts with iodine by oxidative decarbonylation to give a single isomer of the carbene-C ,N chelate tricarbonyl dihalogeno tungsten(II) complex [(CO)3I2/ W C(Ph)NHC5H4N /-o ] (5). The analogous reaction of 4 with bromine affords two interconvertin...

Hydroxycarbene complexes have been proposed as intermediates in industrial processes such as the Fischer-Tropsch process and hydroformylation. As part of the overall synthesis of an aryltethered version of a chromium hydroxycarbene complex we have examined three synthetic routes toward the brominated biphenyl chromium tricarbonyl compound (η-2’-bromobiphenyl)Cr(CO)3, which is an immediate precu...

The in vivo biodistribution of liposomal formulations greatly influences the pharmacokinetics of these novel drugs; therefore the radioisotope labeling of liposomes and the use of nuclear imaging methods for in vivo studies are of great interest. In the present work, a new procedure for the surface labeling of liposomes is presented using the novel 99mTc-tricarbonyl complex. Liposomes mimicking...

Over the recent years, several Re(I) organometallic compounds have been shown to be toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity towards cancer tissues to be used as novel chemotherapeutic agents. In this study, we probe the potential of two known N,N-bis(quinolinoyl) Re(I) tricarbonyl complex derivatives, namely Re(I) tricarbonyl [N,N-bis(quinolin-...

New luminescent dinuclear rhenium(I) tricarbonyl complex-PNA conjugates have been synthesized through a reliable solid-phase synthetic methodology. Their photophysical properties have been measured. The most luminescent Re-PNA conjugate 7 showed interesting two-photon absorption (TPA) properties, that were exploited for imaging experiments, to demonstrate its easy uptake into living cells.

The electrochemical and photochemical catalytic reductions of CO2 using N,O and N,S-NHC-containing dicarbonyl rhenium(i) bipyridine complexes have been investigated. By replacing the carbonyl ligand in tricarbonyl rhenium(i) complexes with a weaker π-accepting ligand, the characteristic MLCT transitions shifted to lower energy. This makes photocatalysts capable of harvesting low-energy visible ...

Carbon monoxide-releasing molecules (CO-RMs) are compounds capable of delivering controlled amounts of CO within a cellular environment. Ruthenium-based carbonyls [tricarbonyldichloro ruthenium(II) dimer and tricarbonylchloro-(glycinato)ruthenium(II)] and boronacorbonates (sodium boranocarbonate) have been shown to promote vasodilatory, cardioprotective, and anti-inflammatory activities in a va...

We report a series of complexes synthesized from the chemical reduction of the fac-tricarbonyl complex Re(bpy)(CO)(3)Cl. Synthesis and characterization of [Re(bpy)(CO)(3)](2), [Re(bpy)(CO)(3)](2)(-), and Re(bpy)(CO)(3)(-) are presented. The Re(bpy)(CO)(3)(-) anion has long been postulated as the active species that reacts with carbon dioxide in the electrochemical reduction of CO(2).