The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5alpha and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions. The crystal structure of TRIM21 PRYSPRY in complex with its target Ig...

We study the distributed control of heating, ventilation, and air conditioning systems in buildings. We present and compare two control design techniques. In the first part, a one-step distributed model predictive controller (DMPC) is introduced. We compute the explicit state-feedback solution and show how to implement it on existing networked buildings control platforms. In the second part, we...

The male-sterile ms2 mutant has been known for 40 years and has become extremely important in the commercial production of wheat. However, the gene responsible for this phenotype has remained unknown. Here we report the map-based cloning of the Ms2 gene. The Ms2 locus is remarkable in several ways that have implications in basic biology. Beyond having no functional annotation, barely detectable...

Regularization is essential for avoiding over-fitting to training data in network optimization, leading better generalization of the trained networks. The label noise provides a strong implicit regularization by replacing target ground truth labels examples uniform random labels. However, it can cause undesirable misleading gradients due large loss associated with incorrect We propose first-ord...

Adjusting a vessel's trim and draught to enhance resistance characteristics is promising strategy improve the energy efficiency of maritime transport. However, vast majority scientific effort has been directed at such gains in deep, unrestricted waters. Shallow confined waters modify flow pressure distribution around ship, altering considerably curve. This study aims elucidate increase effects ...

The tripartite motif (TRIM) of nuclear factor 7 is required for its association with transcription units" (2007). Peter Jones Lab. 22.

Cutting stock problems are within knapsack optimization problems and are considered as a non-deterministic polynomial-time (NP)-hard problem. In this paper, two-dimensional cutting stock problems were presented in which items and stocks were rectangular and cuttings were guillotine. First, a new, practical, rapid, and heuristic method was proposed for such problems. Then, the ...

The objective of the NASA Aviation Safety Program is to improve the safety of current and future aircraft operating in the National Airspace System. Research under this program has focused on vehicle design, construction, operation and maintenance. Reducing aircraft loss of control accidents is critical to increasing aviation safety as it is the largest and most fatal aircraft accident category...

In this paper, we introduce a design criterion for motion primitives of a helicopter when engine failure occurs. A flight plan followed by such a helicopter after it has established autorotation consists of concatenation of such well-defined motion primitives. A library of primitives act as an useful finite action space for a motion planner to search over. Subject to the constrained flight dyna...