Triterpenoid saponins isolated and identified from natural resources during the period April, 2007-December, 2012 are reviewed. Current techniques used in their isolation and structure determination are discussed. New triterpenoid saponins isolated along with their occurrence, selected physical data, spectroscopic methods used for their identification and the 13C NMR data of the novel aglycones...

Four new dammarane-type triterpenoid saponins, chikusetsusaponin FT(1) (1), chikusetsusaponin FT(2) (2), chikusetsusaponin FT(3) (3), chikusetsusaponin FT(4) (4), and six known triterpenoid saponins, chikusetsusaponin FK(4) (8), chikusetsusaponin FK(5) (9), chikusetsusaponin FK(2) (10), chikusetsusaponin FK(3) (11), chikusetsusaponin LN(4) (12), and chikusetsusaponin IVa (14), were isolated fro...

Recently the number of studies investigating triterpenoid saponins has drastically increased due to their diverse and potentially attractive biological activities. Currently the literature contains chemical structures of few hundreds of triterpenoid saponins of plant and animal origin. Triterpenoid saponins consist of a triterpene aglycone with one or more sugar moieties attached to it. However...

Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyph...

many different plant species synthesize triterpenoid saponins as part of their normal programme of growth and development. examples include plants that are exploited as sources of drugs. interest in these molecules stems from their medicinal properties, antimicrobial activity, and their likely role as determinants of plant disease resistance. daisy (bellis perennis l.) accumulates triterpenoid ...

Anemone flaccida Fr. Schmidt, a family of ancient hopanoids, have been used as traditional Asian herbs for the treatments of inflammation and convulsant diseases. Previous study on HeLa cells suggested that triterpenoid saponins from Anemone flaccida Fr. Schmidt may have potential antitumor effect due to their apoptotic activities. Here, we confirmed the apoptotic activities of the following fi...

Seven new dammarane-type triterpenoid saponins, chikusetsusaponin FK1 (1), chikusetsusaponin FK2 (2), chikusetsusaponin FK3 (3), chikusetsusaponin FK4 (4), chikusetsusaponin FK5 (5), chikusetsusaponin FK6 (6), and chikusetsusaponin FK7 (7), and eleven known triterpenoid saponins, ginsenoside Rb3 (9), ginsenoside Rc (10), chikusetsusaponin VI (11), ginsenoside Re (12), ginsenoside Rg1 (13), pseu...

dental caries, periodontitis and other mucosal diseases are caused by a complex community of microorganisms. this study aimed to investigate the antimicrobial properties of saponins of four important oil yielding medicinal plant extracts on selected oral pathogens that are involved in such diseases.saponins were extracted from bauhinia purpurea, madhuca longifolia, celastrus paniculatus and sem...

BACKGROUND Platycodon grandiflorum is the only species in the genus Platycodon of the family Campanulaceae, which has been traditionally used as a medicinal plant for its lung-heat-clearing, antitussive, and expectorant properties in China, Japanese, and Korean. Oleanane-type triterpenoid saponins were the main chemical components of P. grandiflorum and platycodin D was the abundant and main bi...

Ilex asprella, which contains abundant α-amyrin type triterpenoid saponins, is an anti-influenza herbal drug widely used in south China. In this work, we first analysed the transcriptome of the I. asprella root using RNA-Seq, which provided a dataset for functional gene mining. mRNA was isolated from the total RNA of the I. asprella root and reverse-transcribed into cDNA. Then, the cDNA library...