نتایج جستجو برای: trnapro

تعداد نتایج: 67  

2016
Juthamas Jaroensuk Sopapan Atichartpongkul Yok Hian Chionh Yee Hwa Wong Chong Wai Liew Megan E McBee Narumon Thongdee Erin G Prestwich Michael S DeMott Skorn Mongkolsuk Peter C Dedon Julien Lescar Mayuree Fuangthong

Bacteria respond to environmental stresses using a variety of signaling and gene expression pathways, with translational mechanisms being the least well understood. Here, we identified a tRNA methyltransferase in Pseudomonas aeruginosa PA14, trmJ, which confers resistance to oxidative stress. Analysis of tRNA from a trmJ mutant revealed that TrmJ catalyzes formation of Cm, Um, and, unexpectedly...

Journal: :Nucleic acids research 1982
T Sekiya R Nishizawa K Matsuda Y Taya S Nishimura

A lambda clone carrying a rat DNA fragment of 11.9 kb was isolated from a rat gene library with total rat tRNA as a probe. Nucleotide sequence analysis revealed that the DNA fragment contained six tRNA genes, three for tRNAPro and three for tRNALys. Of the six genes all but one tRNAPro gene have the same polarity. Each tRNA gene is separated by a DNA region of 0.1 to 3.6 kb. The 5'-flanking reg...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Eric M Danhart Marina Bakhtina William A Cantara Alexandra B Kuzmishin Xiao Ma Brianne L Sanford Marija Košutić Yuki Goto Hiroaki Suga Kotaro Nakanishi Ronald Micura Mark P Foster Karin Musier-Forsyth

Molecular sieves ensure proper pairing of tRNAs and amino acids during aminoacyl-tRNA biosynthesis, thereby avoiding detrimental effects of mistranslation on cell growth and viability. Mischarging errors are often corrected through the activity of specialized editing domains present in some aminoacyl-tRNA synthetases or via single-domain trans-editing proteins. ProXp-ala is a ubiquitous trans-e...

Journal: :Nucleic acids research 1982
L Corbo G Ciliberto C Traboni R Santamaria F Cimino R Cortese F Salvatore

Purified tRNA genes are expressed when microinjected into the nucleus of X.laevis oocytes. In this paper we describe a method to assay the capacity to be aminoacylated of the tRNA transcribed in the frog oocytes. The method exploits the radiochemical purity of the transcript and relies on the binding of aminoacyl-tRNA but not of uncharged tRNA to purified elongation factor EF-Tu. We also presen...

Journal: :Nucleic acids research 1978
F J Schmidt W H McClain

The biosynthesis of bacteriophage T4 tRNAPro, tRNASer, and tRNAIle requires enzymatic removal of extra nucleotides from the 3' terminus of the respective precursor RNAs. A ribonuclease activity capable of catalyzing such reactions has been partially purified from uninfected Escherichia coli using an artificial precursor RNA as substrate. A number of ribonuclease activities were resolved during ...

Journal: :acta medica iranica 0
babak rahmani department of medical genetics, faculty of medicine, tehran university of medical sciences, tehran, iran. cyrus azimi genetics group, cancer research center, cancer institute, tehran university of medical sciences, tehran, iran. ramesh omranipour surgical oncology group, cancer research center, cancer institute, tehran university of medical sciences, tehran, iran. reza raoofian department of medical genetics, faculty of medicine, tehran university of medical sciences, tehran, iran. kazem zendehdel cancer research center, cancer institute, tehran university of medical sciences, tehran, iran. samira saee-rad department of medical genetics, faculty of medicine, tehran university of medical sciences, tehran, iran.

the mitochondrial dna (mtdna) mutations in mitochondrial coding and non coding regions seem to be important in carcinogenesis. the aim of this investigation was to evaluate coding region (mt-trnaphe and trnapro) and non-coding sequence, mitochondrial displacement loop (mtdna d-loop), in the cancerous and non-cancerous lesions of iranian patients with breast cancer (bc). genomic dna was extracte...

2017
Byung-Sik Shin Takayuki Katoh Erik Gutierrez Joo-Ran Kim Hiroaki Suga Thomas E. Dever

Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that the translation factor eIF5A and its bacterial ortholog EF-P bind in the E site of the ribosome where they contact the peptidyl-tRNA in the P site and play a critical role in promoting the synthesis of polyproline p...

Journal: :Molecular and cellular biology 1996
V Stribinskis G J Gao P Sulo Y L Dang N C Martin

Rpm2p is a protein subunit of Saccharomyces cerevisiae yeast mitochondrial RNase P, an enzyme which removes 5' leader sequences from mitochondrial tRNA precursors. Precursor tRNAs accumulate in strains carrying a disrupted allele of RPM2. The resulting defect in mitochondrial protein synthesis causes petite mutants to form. We report here that alteration in the biogenesis of Rpm1r, the RNase P ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید