Background: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion ex...

the freezing and thawing process not only is associated with serious damage to sperm such as damage to the plasma membrane and the acrosomal membrane but also changes the membrane permeability to some ions including calcium. also, the generation of oxygen free radicals is increased during the freezing-thawing process. the purpose of this study was to evaluate of the effects of trolox as an anti...

LDL resistance to oxidation is characterized by the lag time that precedes the rapid generation of conjugated dienes in copper-induced oxidation. Lag time (y) is described by the equation y = kx + a, where k is the efficacy constant of alpha-tocopherol (alpha-TOH), x the alpha-TOH content of LDL, and a the alpha-TOH-independent variable, all of which show considerable between-subject variabilit...

Although arsenic trioxide (As(2)O(3)) is an effective therapy in acute promyelocytic leukemia (APL), its use in other malignancies is limited by the toxicity of concentrations required to induce apoptosis in non-APL tumor cells. We looked for agents that would synergize with As(2)O(3) to induce apoptosis in malignant cells, but not in normal cells. We found that trolox (6-hydroxy-2,5,7,8-tetram...

Background: Since the deleterious effects of reactive oxygen species (ROS) during sperm cryopreservation can be overcome by antioxidants, post-thaw human sperm quality may perhaps profit from adding antioxidants to the extender media prior to cryopreservation. This study evaluated the effects of different concentrations of Trolox supplementation to cryo-protective media on post-thaw motility an...

Excessive receptor activator of NF-kappaB ligand (RANKL) signaling causes enhanced osteoclast formation and bone resorption. Thus, down-regulation of RANKL expression or its downstream signals may be a therapeutic approach to the treatment of pathological bone loss. In this study, we investigated the effects of Trolox, a water-soluble vitamin E analogue, on osteoclastogenesis and RANKL signalin...

The ability of the water-soluble Vitamin E analog, Trolox, to prevent the toxic effects of copper exposure on the behavior and neuronal physiology of the freshwater oligochaete Lumbriculus variegatus was examined. Trolox produced a concentration-dependent increase in the 24 h LC(50) for copper exposure, with 100 microM Trolox elevating the LC(50) by almost seven-fold (from 0.36 to 2.43 microM)....

PURPOSE Previous studies have shown that newborn rats exposed to hyperoxia within the first 2 weeks of life develop vasculopathy in addition to permanent changes in retinal structure and function. It has also been suggested that free radicals may be the source of these pathologic effects. Trolox C, a water-soluble analogue of vitamin E, was previously shown to limit the vascular consequences of...

ischemia has an important role in spread of pathologic injuries in the neuropathies. it is widely accepted that most damages such as reperfusion injuries, are related to the activity of free radicals. apoptotic signaling was exacerbated by free radicals. the aim of this study was to evaluate the neuroprotective effect of human chorionic gonadotropin (hcg) and vitamin e (trolox) in the hippocamp...

Corresponding Author: Julio C.M. Soares Universidade Federal do PampaUNIPAMPA-Campus de Caçapava do Sul, RS, Brazila Email: [email protected] Abstract: The intensification of the use of artificial insemination in the swine industry has increased the interest to develop proper conditions to store semen better for longer periods of time without affecting its fertility. Trolox is a vitamin E ...