We present information on age related changes of thyroid hormone levels in bonobos (N = 96) and chimpanzees (N = 100) ranging between one and 56 years of age. Fresh urine samples were used for hormone measurements with a commercial competitive total triiodothyronine (T3) ELISA. In both species, immature individuals had higher TT3 levels than adults and there was a marked decrease in TT3 levels ...

The effect of protein energy malnutrition (PEM) in the children on serum levels of total thyroxine (TT4), total triodothyronine (TT3) and thyrotropin (TSH) were evaluated. There were 107 children aged 2 to 60 months in the malnutrition group and 54 healthy age and sex matched controls. Serum TT4 and TT3 were all reduced in the malnutrition group. This decrease in TT3 was more significant (p < 0...

BACKGROUND Because total thyroid hormone testing is performed on many automated clinical chemistry instruments, the IFCC Scientific Division commissioned the Working Group for Standardization of Thyroid Function Tests to include total thyroxine (TT4) and total triiodothyronine (TT3) in its standardization efforts. METHODS Existing SI-traceable reference measurement procedures (RMPs) were used...

Background: In normal pregnancy, changes in thyroid function are well acknowledged; however, information about thyroid function in gestational hypertension (GH) is scanty. Hypertensive disorders complicating pregnancy are common and contribute greatly to prenatal and maternal morbidity and mortality in the developing countries. The aim of this study was to investigate thyroid functions in pregn...

To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, F...

BACKGROUND Thyroid dysfunction is associated with the use of tyrosine kinase inhibitors (TKI) in people. HYPOTHESIS/OBJECTIVES To determine whether dysfunction in the hypothalamic-pituitary-thyroid axis occurs in dogs receiving the TKI, toceranib phosphate. ANIMALS Forty-three client-owned dogs with cancer. METHODS Prospective, observational study. Concentrations of total thyroxine (TT4),...

Exposure to certain perfluoroalkyl acids (PFAAs) can have considerable effects on the endocrine and immune systems, although such remain largely uncharacterized in wildlife. Using an apex avian predator, we investigated possible relationships of thyroid hormones (THs), specifically free (F) total (T) thyroxine (FT4; TT4) triiodothyronine (FT3; TT3), expression immune-related microRNA biomarker ...

Our recent study showed that monocrotophos (MCP) pesticide disrupted the hypothalamic-pituitary-thyroid (HPT) axis in male goldfish (Carassius auratus); however, the effects of MCP on the thyroid system in female goldfish are remain unclear. In the present study, plasma thyroid hormone (TH) and thyroid-stimulating hormone (TSH) levels were evaluated in female goldfish exposed to 0.01, 0.10, and...

Context: The hormonal factors involved in the regulation of peak bone mass in men have not been fully investigated. Aside from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis, and are additional candidate determinants of adult bone mass. Objective: We aimed to investigate between-subject physiological variation in free and total t...