Two crystalline and nano-sized new Cu(II) MOFs {[Cu(ttpa)(1,3-bdc)(H2O)]·CH3OH}n (Cu(ttpa)-1) {[Cu(ttpa)(mip)(H2O)]•2H2O} (Cu(ttpa)-2) were prepared characterized (ttpa ​= ​tris(4-(1,2,4-triazol-1-yl)phenyl)amine, 1,3-bdc ​1,3-benzenedicarboxylate, mip ​5-methyl-isophthalate) by hydrothermal method sonochemical method. Cu(ttpa)-1 Cu(ttpa)-2 exhibited the 2D network with point symbol {44⋅62}{44⋅...

BACKGROUND Ataxia with vitamin E deficiency is a recessive autosomal neurodegenerative disorder resembling the Friedreich ataxia phenotype but is due to mutations in the alpha-tocopherol transfer protein (TTPA) gene. In a recent article, we described a patient with ataxia carrying reduced serum vitamin E levels and showing CTA/CTG expansions of 320 triplet repeats in the SCA8 gene. OBJECTIVES...

BACKGROUND AND OBJECTIVES Deficiency in protein S, which is a glycoprotein with anticoagulant activity, increases the risk for thromboembolic events. This report aimed at addressing anesthetic management of protein S deficient obstetric patient. CASE REPORT Protein S deficient patient, at 25 weeks gestation, presented the following lab results: INR = 0.9, TTPA = 32 s (control 25.6), protein S...

Oxidative stress has a ubiquitous role in neurodegenerative diseases and oxidative damage in specific regions of the brain is associated with selective neurodegeneration. We previously reported that Alzheimer disease (AD) model mice showed decreased insulin-degrading enzyme (IDE) levels in the cerebrum and accelerated phenotypic features of AD when crossbred with alpha-tocopherol transfer prote...

α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the α-tocopherol transfer protein for the murine version (Ttpa(-/)(-)) mice which lack the α-to...

loud storage mainly offers an on-demand data outsourcing servicing model which is gaining popularity through its elasticity and low maintenance cost. In such cases Security concerns arises when data is outsourced to a third-party cloud storage provider. The data that is stored in the cloud might get corrupted due to some malicious programs or due to an adversary. Considering the existing method...

The study assessed effect of farm machinery on both physical and hydraulic properties agricultural soils used for rice cultivation in northern Ghana.  Two tractor models were the field experiment with tests soil sampling points classified as tyre passage area (TTPA), ploughed (PA) unploughed (UPA). Randomised Complete Block Design (RCBD) 3 blocks, treatments, 9 replications data analysed u...

The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring TTP's significance during fetal development. TTP an...

BACKGROUND Ataxia with vitamin E deficiency (AVED) is an autosomal recessive disorder that usually presents with ataxia, areflexia, and proprioceptive and vibratory sensory loss. Dystonia has been reported rarely. CASE REPORT An 11-year-old female presented with dystonic head tremor and cervical and bilateral arm dystonia. Her 14-year-old older brother had dystonic head tremor and generalized...

La heparina no fraccionada (HNF) es el anticoagulante de mayor uso en pacientes hospitalizados. El rango terapéutico (RT) se definió adultos relación a la prolongación del Tiempo Tromboplastina Parcial activado (TTPa). Sin embargo, recomendación mantener un con anti factor X (antiFXa). Como esta técnica más compleja realizar y menos disponible, recomienda hacer curvas locales correlación TTPa A...