introduction: idiopathic pulmonary fibrosis (ipf) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. in the adults type i and ii pneumocytes, forms components of the alveolar epithelial cells. in this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type i and ii pneumocytes) in th...

Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and usually fatal lung disease of unknown etiology for which no effective treatments currently exist. In the adults type I and II pneumocytes, forms Components of the alveolar epithelial cells. In this study, we investigated the effect of thalidomide on the alveolar epithelial cells (type I and II pneumocytes) in ...

OBJECTIVE Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung dis...

We report a case of primary lung adenocarcinoma with type II pneumocyte characteristics. Electron microscopic examination demonstrated that the tumour cells had well-developed microvilli and cytoplasmic lamellar inclusion bodies. These ultrastructural features are similar to those seen in type II pneumocytes of normal lung tissue. Western blot analysis, using monoclonal antibody against human s...

Guinea pigs were exposed to 1% CO2 in a mixture of 21% O2, balance N2 and were killed at weekly intervals, together with control animals housed in the same type of environmental chamber and exposed to normal ambient CO2. The exposed animals showed a persistent elevation of PaCO2, averaging about 4 mmHg, and a small decrease in pH (-0.04 units). During the whole exposure period standard bicarbon...

Douglas, W. H. J., K. E. Schaefer, A. A. Messier, and S. M. Pasqualc. 1979. Proliferation of pneumocyte II cells in prolonged exposure to 1% CO«. Undersea Biomed. Res. Sub. Suppl.: S135-S142.—Guinea pigs were exposed to \% CO» in a mixture of 21% Oj, balance N, and were killed at weekly intervals, together with control animals housed in the same type of environmental chamber and exposed to norm...

Chemokine receptors control several fundamental cellular processes in both hematopoietic and structural cells, including directed cell movement, i.e., chemotaxis, cell differentiation, and proliferation. We have previously demonstrated that CXCR3, the chemokine receptor expressed by Th1/Tc1 inflammatory cells present in the lung, is also expressed by human airway epithelial cells. In airway epi...