INTRODUCTION Insulin therapy plays a critical role in the treatment of type 1 and type 2 diabetes mellitus. However, there is still a need to find basal insulins with 24-hour coverage and reduced risk of hypoglycemia. Additionally, with increasing obesity and insulin resistance, the ability to provide clinically necessary high doses of insulin at low volume is also needed. AREAS COVERED This ...

Synthetase Involved in Phosphinothricin Tripeptide Biosynthesis Jin-Hee Lee, Bradley S. Evans, Gongyong Li, Neil L. Kelleher, and Wilfred A. van der Donk SUPPORTING INFORMATION 1. Chemical Synthesis of Substrates Substrates. AcDMPT was synthesized using the radical addition of hypophosphorous acid to vinyl glycine as the key step as described previously (1) and similar to a procedure reported w...

BACKGROUND Initiation and titration of human regular U-500 insulin (U-500R) with a dosing algorithm of either thrice daily (TID) or twice daily (BID) improved glycemic control with fewer injections in patients with type 2 diabetes treated with high-dose, high-volume U-100 insulin. The objective of this analysis was to compare patient-reported outcomes between U-500R TID and BID treatment groups...

Abstract Introduction: Diabetes mellitus and obesity is associated with increased risk of pancreatic cancer which has been postulated to be due beta cell dysfunction insulin resistance. Pancreatic also exerts its effect on cells, reducing secretion, affecting glucose uptake increasing We present a case adenocarcinoma severe resistance uncontrolled diabetes reversed after tumor removal. Clinical...

introduction the main perspective in seasonal prediction of precipitation is presentation of a qualitative prediction for upcoming seasons. the information gained from such predictions can be used for decision making in various disciplines such as agriculture, water management and hydropower production. besides, it can help us reduce the adverse effects of climatic changes like drought and floo...

Photoacoustic molecular imaging is an emerging technology offering non-invasive high resolution imaging of the molecular expressions of a disease using a photoacoustic imaging agent. Here we demonstrate for the first time the utility of single walled carbon nanotubes (SWNTs) as targeted imaging agents in living mice bearing tumor xenografts. SWNTs were conjugated with polyethylene-glycol-5000 c...

A ll new therapeutic agents, and updated versions of older ones, must be submitted for review by regulatory agencies. While this process is complex, its goals as stated by the U.S. Food and Drug Administration (FDA) are straightforward. The main aim is to determine “whether the drug is safe and effective in its proposed use(s), and whether the benefits of the drug outweigh the risks” (1). Addit...