background: regarding the strong differentiation and anti-leukemic activity of dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. the aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using u937 cells. met...

background and objective: vascular endothelial growth factor (vegf) is a cytokine which is overexpressed in many malignant cancers including leukemia. vegf plays an important role in tumor invasion and metastasis. determination of the pattern of vegf expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

Background and Objective: Vascular endothelial growth factor (VEGF) is a cytokine which is overexpressed in many malignant cancers including leukemia. VEGF plays an important role in tumor invasion and metastasis. Determination of the pattern of VEGF expression in human leukemic cell lines could be useful not only in screening of new antileukemic agents but also to study the mechanism of their ...

Background: Pregabalin, a selective inhibitor of voltage dependent calcium channels has been used for treatment of epilepsy, fibromyalgia, generalized anxiety disorder and especially neuropathic pains. The anti-inflammatory properties of pregabalin in some pathologic conditions like orofacial pain and streptozotocin-induced diabetic mice have been reported. Effectiveness of pregabalin in treatm...

Background: Regarding the strong differentiation and anti-leukemic activity of Dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. The aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using U937 cells. Me...

Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leuk...

treatment of human promonocytic leukemic cell line u937 with mild hyperthermia in the temperature range of 40-43°c resulted in differentiation of these cells into monocyte/macrophage-like cells in a heat dose and time dependent manner. this process was accompanied by marked morphological, functional and proliferational changes. u937 cells which normally grow in supension in the logarithmic phas...

Background: β-Blockers have shown considerable cytotoxic, anti-tumor and anti-angiogenic effects. Metoprolol, a β-Blocker with anti-inflammation, anti-tumor and anti-angiogenic properties has been widely used for treatment of some cardiovascular diseases such as angina, hypertension, heart failure and myocardial infraction. Limited data exist about the cytotoxic effects of metoprolol on human c...

background: interfering with cell proliferation and survival is a critical role for antineoplastic drugs leading to cell death through induction of apoptosis. alternative treatments with herbal extracts offer insights into acute myeloid leukemia (aml) therapy. parthenolide (ptl), an extract from feverfew, induces apoptosis in primary human leukemia stem cells (lscs) and bulk leukemic cell popul...