undifferentiated nasopharyngeal corcinoma is frequently misdiagnosed as large cell malignant lymphoma. the aim of this study is to evaluate the diagnostic role of immunohistochemistry and electron microscopy in this tumor. 81 cases of nasopharyngeal carcinoma were studied. patients ranged from 9-90 years in age (mean: 48.5 years). the age incidence curve was bimodal with two peaks in 2-3 and 5-...

Undifferentiated carcinoma of nasopharyngeal type arising in the larynx is unusual. This type of carcinoma-which occurs almost exclusively in nasopharynx-is very infrequent in the larynx (0.2%). Till date only 17 cases are reported in the medical literature. We present the clinical and histopathological findings along with the management of one additional case of undifferentiated carcinoma of n...

Lymphoepithelial carcinoma is an extremely rare malignant tumor, especially those localized at the head and neck region. The histological prototype of lymphoepithelial undifferentiated nasopharyngeal carcinoma. Herein, we report a case tumor in left submandibular gland 20-year-old male. mass was surgically excised with gland, specimen pathologically confirmed to be

BACKGROUND Solitary splenic metastases are a rare occurrence, and the nasopharyngeal carcinoma represents one of the most uncommon primary sources. The present study aimed to describe a rare case of a solitary single splenic metastasis from nasopharyngeal carcinoma and to assess the number of cases of isolated nasopharyngeal carcinoma metastases to the spleen reported in the literature. MAIN ...

S-100 antigen containing cells with dendritic features, recognisable by morphological and immunohistochemical criteria as belonging to the Langerhans' or interdigitating reticulum cell type, have been found in undifferentiated nasopharyngeal carcinoma. The presence of these cells, which have a special function of antigen presentation in immune responses, may be involved in a possible modulation...

Undifferentiated nasopharyngeal carcinoma is a result of environmental factors, in particular EBV infection, affecting genetically susceptible individuals. The familial risk of nasopharyngeal carcinoma is among the highest of any malignancy. Whether this susceptibility is restricted to nasopharyngeal carcinoma is unknown as information on the risk of other cancers in relatives is limited. We di...

Epstein-Barr virus (EBV) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (UCNT, World Health Organization type III), which is the dominant histopathological type in high-risk areas. The major EBV oncogene is latent membrane protein 1 (LMP1). LMP1 gene shows variability with different tumorigen...