A novel approach is proposed for modeling loop regions in proteins. In this approach, a prerequisite sequence-structure alignment is examined for regions where the target sequence is not covered by the structural template. These regions, extended with a number of residues from adjacent stem regions, are submitted to fold recognition. The alignments produced by fold recognition are integrated in...

We nave implemented a restricted .:lommn parser called Plume "M Building on previous work at Carneg=e-Mellon Unfvers=ty e.g. [4, 5. 81. Plume s approacn to oars=ng ~s based on semantic caseframe mstant~a~on Th~s nas the advantages of effic=ency on g r i n ~at ical ,nput. and robustness in the face of ungrammatmcal tnput Wh~le Plume ~s well adapted to s=mpte ,:;~ectaratwe and ~mperat=ve utteranc...

Since its introduction by Evans (1982), the generality constraint (GC) has been invoked by various philosophers for different purposes. Our purpose here is, first, to clarify what precisely the GC states by way of an interpretive framework, the GC Schema, and second, to demonstrate in terms of this framework some problems that arise if one invokes the GC (or systematicity) without clearly speci...

Since its introduction by Evans (1982), the generality constraint (GC) has been invoked by various philosophers for different purposes. Our purpose here is, first, to clarify what precisely the GC states by way of an interpretive framework, the GC Schema, and second, to demonstrate in terms of this framework some problems that arise if one invokes the GC (or systematicity) without clearly speci...

Many genes expressed in the human genome have not been identified despite intensive efforts. We observed that the presence of long poly(dA/dT) sequences in the 3' end of cDNA templates contributes significantly to this problem, because the hybrids formed randomly between poly(dA) and poly(dT) sequences of unrelated cDNA templates lead to loss of many templates in the normalization/subtraction r...