background: hepatitis activity index (hai) and fibrosing stage are two important findings during the evaluation of liver samples in patients with chronic hepatitis b. the aim of this study was to determine the hai and fibrosing stage in patients with anti-hbe positive chronic hepatitis b. methods: liver biopsy slides of 72 patients were evaluated at the department of pathology in two teaching h...

conclusions it is concluded that most hbeag negative hepatitis b patients with serum hbv dna level of 2000-20000 iu/ml, persistent normal alt concentration, and no or mild liver damage on biopsy can be clinically managed as hbv inactive carriers. results two hundred forty-three hbeag negative hepatitis b patients were stratified into three groups based on to their hbv dna level including group ...

background hepatitis c virus (hcv) infection is one the major health concern among the infected transplant patients. considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. objectives the current study was conducted to determine the hepatitis c virus rna le...

background more than two billion people have been exposed to hepatitis b virus (hbv) worldwide. furthermore, four hundred million of them are infected with chronic hbv infection. the predominant mutation of the precore region involves a g to a change at nucleotide1896, which creates a premature stop codon at codon 28. two mutations of a1762t and g1764a are reported as the most prevalent mutatio...

background: serial measurement of  hepatitis b virus (hbv) dna levels in the liver and its relation with liver damage and serum hbv dna levels are guide to begin and/or end a treatment course. this study evaluated the relationship between liver hepatitis b dna viral load with liver histology in patients with chronic hepatitis b (hbv). methods:  thirty patients with chronic anti-hbe positive hep...

background: viral load and alanine aminotransferase (alt) levels may not be the key points for making a decision in the treatment of anti-hbe positive chronic hepatitis b. the purpose of this study was to assess the histological evaluation of liver to find the need for treatment on 72 patients with anti-hbe positive chronic hepatitis b. methods: the liver biopsy slides of the 72 patients (56 su...

background diagnosis and control programs for infectious diseases among immigrants are the most important aspects of epidemiological studies for both origin and destination countries. data about hepatitis b virus (hbv) infection among the afghan immigrants in iran is limited. objectives to the best of hbv treatment and prevention in afghan immigrants in iran, the present study was conducted to ...

background: successful treatment to eliminate hcv rna depends on the identified genotype. in the present study, we com­pared the frequency of different hcv genotypes, during four years study (2004 till 2008).  methods: sera specimens were received from 16 provinces of iran. we used high pure viral nucleic acid purification kit for extraction and samples were tested with improved form of rt-pcr ...

conclusions our findings indicate that patients with the homozygous cc genotype in the il28b gene had a significantly higher rate of response to treatment than those with the tt or ct genotypes. nor does the il28b rs12979860 polymorphism affect the viral load. results the genotype frequencies of rs12979860 polymorphism in group 1 were cc (28.9%), ct (37.8%) and tt (33.3%) and in group 2 were cc...

objective(s): htlv-i and hiv virus quantification is an important marker for assessment of virus activities. since there is a direct relationship between the number of virus and disease progression, htlv- i and hiv co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated.   materials and method...