نتایج جستجو برای: vista

تعداد نتایج: 7878  

2011
Li Wang Rotem Rubinstein Janet L. Lines Anna Wasiuk Cory Ahonen Yanxia Guo Li-Fan Lu David Gondek Yan Wang Roy A. Fava Andras Fiser Steve Almo Randolph J. Noelle

The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated V-domain Ig suppressor of T cell activation (VISTA). VISTA is primarily e...

2010
Lijuan Xu Lianhai Wang Lei Zhang Zhigang Kong

A method to extract information of network connection status information from physical memory on Windows Vista operating system is proposed. Using this method, a forensic examiner can extract accurately the information of current TCP/IP network connection information, including IDs of processes which established connections, establishing time, local address, local port, remote address, remote p...

Journal: :Cancer research 2014
Isabelle Le Mercier Wenna Chen Janet L Lines Maria Day Jiannan Li Petra Sergent Randolph J Noelle Li Wang

V-domain Ig suppressor of T-cell activation (VISTA) is a novel negative checkpoint ligand that is homologous to PD-L1 and suppresses T-cell activation. This study demonstrates the multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances protective antitumor immunity. VISTA is highly expressed on myeloid cells and Foxp3(+)CD4(+) regulatory cells, but not...

Journal: :Nucleic acids research 2004
Kelly A. Frazer Lior Pachter Alexander Poliakov Edward M. Rubin Inna Dubchak

Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here, we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-gsd.lbl.gov/vista/ was launched in the summer of 2000 and was designed to align long genomic sequences and visualize these alignments wit...

Journal: :JCI insight 2017
Aaron Prodeus Aws Abdul-Wahid Amanda Sparkes Nicholas W Fischer Marzena Cydzik Nicholas Chiang Mays Alwash Alessandra Ferzoco Nathalie Vacaresse Michael Julius Reginald M Gorczysnki Jean Gariépy

V-domain immunoglobulin suppressor of T cell activation (VISTA) is a recently discovered immune checkpoint ligand that functions to suppress T cell activity. The therapeutic potential of activating this immune checkpoint pathway to reduce inflammatory responses remains untapped, largely due to the inability to derive agonists targeting its unknown receptor. A dimeric construct of the IgV domain...

Journal: :Cancer research 2014
J Louise Lines Eirini Pantazi Justin Mak Lorenzo F Sempere Li Wang Samuel O'Connell Sabrina Ceeraz Arief A Suriawinata Shaofeng Yan Marc S Ernstoff Randolph Noelle

V-domain Ig suppressor of T cell activation (VISTA) is a potent negative regulator of T-cell function that is expressed on hematopoietic cells. VISTA levels are heightened within the tumor microenvironment, in which its blockade can enhance antitumor immune responses in mice. In humans, blockade of the related programmed cell death 1 (PD-1) pathway has shown great potential in clinical immunoth...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Jun Liu Ying Yuan Wenna Chen Juan Putra Arief A Suriawinata Austin D Schenk Halli E Miller Indira Guleria Richard J Barth Yina H Huang Li Wang

V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a negative immune-checkpoint protein that suppresses T-cell responses. To determine whether VISTA synergizes with another immune-checkpoint, programmed death 1 (PD-1), this study characterizes the immune responses in VISTA-deficient, PD-1-deficient (KO) mice and VISTA/PD-1 double KO mice. Chronic inflammation and spontaneous act...

2007
Michael Brudno Alexander Poliakov Simon Minovitsky Igor Ratnere Inna Dubchak

The VISTA portal for comparative genomics is designed to give biomedical scientists a unified set of tools to lead them from the raw DNA sequences through the alignment and annotation to the visualization of the results. The VISTA portal also hosts the alignments of a number of genomes computed by our group, allowing users to study the regions of their interest without having to manually downlo...

2012
H. B. Kekre Sudeep D. Thepade

The automatic construction of large, high-resolution image vistas (mosaics) is an active area of research in the fields of photogrammetry [1,2], computer vision [1,4], medical image processing [4], computer graphics [3] and biometrics [8]. Image stitching is one of the possible options to get image mosaics. Vista Creation in image processing is used to construct an image with a large field of v...

Journal: :Spine 2013
Paul C Ivancic

STUDY DESIGN In vitro biomechanical study. OBJECTIVE Our objective was to determine the effectiveness of cervical collars and cervicothoracic orthoses for stabilizing clinically relevant, experimentally produced cervical spine injuries. SUMMARY OF BACKGROUND DATA Most previous in vitro studies of cervical orthoses used a simplified injury model with all ligaments transected at a single spin...

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