In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters in good to excellent yields. These compounds were further utilized to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) u...

An improved total synthesis of (-)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (-)-julocrotine analogues was synthesized by employing the heterocyclic precursor as an amino input in Ugi four-component reactions (Ugi-4CR) [1].

This presentation discloses a one-pot synthesis of a series of spiropyrroloquinoline isoindolinone and spiropyrroloquinoline aza-isoindolinone scaffolds. The reaction proceeds by the combination of a Ugi four-component reaction (4CR) and two intramolecular cyclizations under metal-free conditions. The proof of the structures relies on analytical investigation and X-ray crystallography.

A three step synthesis of N-unsubstituted tetrazolo γ- and δ-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted γ- and δ-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.

Microstructure and irradiation hardening of V-4Cr-4Ti alloys with different yttrium (Y) contents were studied by self-ion at 550 °C via TEM nano-indentation test technology. The peak damage the V-4Cr-4Ti-xY alloy (x = 0, 0.1, 0.5, 1, wt.%) irradiated 2.5 MeV (V2+) is 8 dpa. Dense dislocation loops observed in all vanadium samples after irradiation. With increase Y content, both average size num...

Correction for ‘Amenamevir by Ugi-4CR’ Xin Li et al. , Green Chem. 2023, 25 1322–1325, https://doi.org/10.1039/D2GC04869H.