Weightlessness is known to induce many pathophysiological changes in various organs and systems in simulated weightlessness animal models. However, there is limited data on the effects of weightlessness on the female reproductive system. In the present study, we used the Morey-Holton hind limb suspension model to simulate weightlessness in female rats. We have shown that this weightlessness ind...

Weightlessness is an extreme environment that can cause a series of adaptive changes in the human body. Findings from real and simulated weightlessness indicate altered cardiovascular functions, such as reduction in left ventricular (LV) mass, cardiac arrhythmia, reduced vascular tone and so on. These alterations induced by weightlessness are detrimental to the health, safety and working perfor...

During everyday life, gravity constantly stresses the cardiovascular system in upright humans by diminishing venous return. This decreases cardiac output and induces systemic vasoconstriction to prevent blood pressure from falling. We therefore tested the hypothesis that entering weightlessness leads to a prompt increase in cardiac output and to systemic vasodilatation and that these effects pe...

Bone loss is a negative balance course especially occurred after long-term space flight for astronauts under weightlessness [1]. Bone remodeling is a dynamic process that requires the coordinated interaction of osteocytes, osteoblasts, and osteoclasts, collaborating in basic multicellular units (BMUs) [2]. Recently,osteocytes are believed to be the mechanosensors of bone, responding to mechanic...

Meleshko, G.!., Yeo Ya. Shepelev: Weightlessness as a Prerequisite for the 1mplementation of Biological Life Suppon System. Acta vet. Bmo 1996,65: 43-50. The implementation of human Biological Life Support System (BLSS) in the conditions of weightlessness requires a broader, ecological approach to the analysis of manifestations of weightlessness in living systems as compared to the traditional ...

During the spaceflight under weightlessness condition, human's brain function may be affected by the changes of physiological effects along with the distribution of blood and body fluids to the head. This variation of brain function will influence the performance of astronauts and therefore create possible harm to flight safety. This study employs 20 male subjects in a 7-day-6° head-down tilted...

Overconfidence has been identified as a source of suboptimal decision making in many real-life domains, with often far-reaching consequences. This study identifies a mechanism that can cause overconfidence and demonstrates a simple, effective countermeasure in an incentive-compatible experimental study. We observed that joy induced overconfidence if the reason for joy (an unexpected gift) was u...