Population stratification can be a serious obstacle in the analysis of genomewide association studies. We propose a method for evaluating the significance of association scores in whole-genome cohorts with stratification. Our approach is a randomization test akin to a standard permutation test. It conditions on the genotype matrix and thus takes into account not only the population structure bu...

BACKGROUND TO THE DEBATE Coronary artery disease is a major cause of death worldwide. Two very different approaches have been proposed as a way of reducing these deaths. The "high risk" approach uses tools such as risk factor scoring and carotid ultrasound to try and identify those at highest risk, and then treats them aggressively. The "population" approach aims to shift the distribution of ri...

the 1288 ah famine in khorasan has been the subject of numerous studies having examined the event with special focus on its causes and short-term effects as well as the reaction of the people and the state to it. this approach has led to general statements and unjustified generalization of the results of such research to the whole iran. the present article is a case study of the 1288 ah famine ...

Schools are increasingly being asked to identify and monitor youth who may be susceptible recruitment toward radical groups. Rather than asking teachers at-risk behaviors, Dianne Gereluk argues here that a whole-school approach help foster belonging connection among is not additive, but central component of safe inclusive schools. Whole-school approaches attend the different power relationships...