BACKGROUND Despite various attempts at modifying usual treatment modalities, anaplastic thyroid cancer (ATC) is still associated with unfavorable prognosis. Results of preclinical investigations are often of limited transferability to clinical tumor biology. Individualized multimodal treatment regimens, including novel growth-inhibiting drugs, might be a future option. METHODS Tumor tissue, f...

The interaction between transplanted cells and host tissues is important for the growth and maintenance of transplanted cells. To analyze the mechanisms of these interactions, a systemic fluorescent protein-expressing mouse is a useful recipient. In this study, we generated a novel NOG strain, which strongly expresses enhanced green fluorescent protein (EGFP; PgkEGFP-NOG), especially in the liv...

BACKGROUND Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated. MATERIALS AND METHODS Forty-four surgically-resected human lung cancer tissues were xenotransplanted into SCID mice. Their blood was collected and the volume of the transplanted tumors was measured regularly. The correlations between the IgG tite...

Growth rate, histolÃ3gica! course, and polymorphic enzyme pattern (glucose 6-phosphate dehydrogenase, glucose phos phate isomerase, and phosphofructokinase) were studied in eight childhood tumors xenotransplanted serially to nude mice. The growth rate of these tumors (three nephroblastomas, one hyper calcémierenal tumor, three rhabdomyosarcomas, and one malig nant histiocytosis) appeared stabl...

In vitro and in vivo investigations have shown that nontoxic treatment with vitamin A (retinol) has an inhibitory effect on the growth of malignant cells. The tumorigenic CaMa-15 cell line responds to both retinol and retinole acid under both anchoragedependent and anchorage-independent conditions, reducing growth or colony formation by at least 50%. To date, there have been few studies on the ...

PURPOSE We investigated the effect of endostatin on differentiation, mobilization, and clonogenic potential of circulating endothelial cell (EC) progenitors, and whether the effect of endostatin was improved by continuous infusion (CI) versus bolus administration. EXPERIMENTAL DESIGN Four-color flow cytometry and clonogenic EC cultures were used to study EC progenitors in tumor-free mice, tum...