Background: Radioactive yttrium glass microspheres are used for liver cancer treatment. These yttrium aluminum silicate microspheres are synthesized from yttrium, aluminum and silicone oxides by melting. There are two known processes used to transform irregular shaped glass particles into microspheres, these ‘spheroidization by flame’ and ‘spheroidization by gravitational fall...

background: radioactive yttrium glass microspheres are used for liver cancer treatment. these yttrium aluminum silicate microspheres are synthesized from yttrium, aluminum and silicone oxides by melting. there are two known processes used to transform irregular shaped glass particles into microspheres, these ‘spheroidization by flame’ and ‘spheroidization by gravitational fall in a tubular furn...

Microspheres containing yttrium (Y) and/or phosphorus (P) around 25 μm are useful for radioembolization therapy because they are activated to β-emitter by neutron bombardment and infused in blood vessels in the neighborhood of tumors to irradiate β-rays to the tumors. In this study, we attempt to prepare Y and P-containing microspheres by spray drying method. Starting solution containing yttriu...

The best chance of cure for patients with liver cancer is surgical removal, but many tumors are too large or invasive. In addition, chemotherapy is frequently unsuccessful in this patient population. A case study is featured involving a patient determined to be a candidate for Yttrium-90 radioembolization, a minimally invasive liver-directed treatment used to target primary and metastatic liver...

We present in vitro and in vivo studies of yttrium-90 (Y)-labelled human serum albumin magnetic microspheres (HSAMMS) as multifunctional agent for bimodal radionuclidehyperthermia cancer therapy. The HSAMMS were produced using a modified emulsificationheat stabilization technique and contained 10-nm magnetite nanoparticles coated with citric acid, distributed as inhomogeneous clusters within th...

Radioembolization (RE) with Yttrium-90 ((90)Y) microspheres is an effective treatment for unresectable liver tumors. The activity of the microspheres to be administered should be calculated based on the type of microspheres. Technetium-99m macroaggregated albumin ((99m)Tc-MAA) single photon emission computed tomography/computed tomography (SPECT/CT) is a reliable assessment before RE to ensure ...

Selective internal radiation therapy (SIRT) with Yttrium-90 (Y90) microspheres is a promising therapy option in patients with advanced hepatocellular carcinoma (HCC). Early detection of therapy response is warranted to ensure adequate ongoing treatment, but size measurements and contrast enhancement are often not conclusive. We aimed to evaluate diffusion weighted imaging (DWI) for early predic...

Transcatheter arterial radioembolization (TARE) with Yttrium-90 ((90)Y)-labeled microspheres has an emerging role in treatment of patients with unresectable hepatocellular carcinoma. Although complication of TARE can be minimized by aggressive pre-evaluation angiography and preventive coiling of aberrant vessels, radioembolization-induced gastroduodenal ulcer can be irreversible and can be life...

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) often present at stages where patients have limited treatment options. Use of selective internal radiation therapy (SIRT) with yttrium-90 (Y-90) resin microspheres has progressed as data increasingly speak to its utility in patients with both intermediate and late stage disease in these cancers. In anticipation of the pend...