Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC pluripotency. Here, we uncover that Jmjd2c facilitates this process by stabilizing the assembly of Mediator-Cohesin complexes at lineage-specific enhancers. Functionally, we show that Jmjd2c is required in ESCs to initiate appropriate g...

I. DE GLISEZINSKI,1,4 I. HARANT,1 F. CRAMPES,1,4 F. TRUDEAU,2 A. FELEZ,1 J. M. COTTET-ÉMARD,3 M. GARRIGUES,1,4 AND D. RIVIERE1,4 1Laboratoire des Adaptations de l’Organisme à l’Exercice Musculaire, Service d’Exploration de la Fonction Respiratoire et de Médecine du Sport, Centre Hospitalier Universitaire Purpan, 31059 Toulouse Cedex, France; 2Département des Sciences de l’Activite Physique, Uni...