Previous studies identified a family of organic anion transport proteins (OATPs), many of which have C-terminal PDZ binding consensus sequences. In particular, the C-terminal four amino acids of Oatp1a1, a transporter on rat and mouse hepatocytes, comprise a consensus binding site for PDZK1. In PDZK1 knockout mice and in transfected cells where PDZK1 expression was knocked down, Oatp1a1 accumul...

Acute otitis media, inflammation of the middle ear, is the most common bacterial infection in children and, as a consequence, is the most common reason for antimicrobial prescription to this age group. There is currently no effective vaccine for the principal pathogen involved, non-typeable Haemophilus influenzae (NTHi). The most frequently used and widely accepted experimental animal model of ...

implant and DMPA appears increasingly important in light of one recent animal study suggesting a relationship between progestin exposure and vaginal atrophy (which might lead to increased risk of HIV infection).6 Although it is premature to extrapolate the findings of this study to humans, the results highlight the importance of correct and consistent condom use among users of hormonal contrace...

The role of the food industry (retailers, manufacturers and food service) in helping consumers eat healthily and sustainably has been receiving considerable attention in recent years. This paper focuses on the challenges facing the food industry and the role of food reformulation in meeting these challenges, through the lens of a public health nutritionist. Attention has been heightened by the ...

Purpose: Implant length, implant surface area, and crown-to-root (c/r) ratio and their relationship to crestal bone levels were analyzed in 2 groups of partially edentulous patients treated with sintered porous-surfaced dental implants. Materials and Methods: One hundred ninety-nine implants were used to restore 74 partially edentulous patients with fixed prostheses. Implants were categorized a...

Cytosine methylation, a common form of DNA modification that antagonizes transcription, is found at transposons and repeats in vertebrates, plants and fungi. Here we have mapped DNA methylation in the entire Arabidopsis thaliana genome at high resolution. DNA methylation covers transposons and is present within a large fraction of A. thaliana genes. Methylation within genes is conspicuously bia...