and Applied Analysis 3 Figure 1: Parameter plane. Let us stress that the head and the body are surrounded by bulbs, of different sizes, that yield to the appearance of attractive cycles of different periods. In this paper, we focus on the study of all bulbs involving attractive cycles of period 2. As we see in the following sections, these attractive 2-cycles also appear in the small black figu...

We generated mice with doxycycline control of a human neurofilament light (NF-L) transgene in the context of the absence (tTA;hNF-L;NF-L(-/-)) or presence (tTA;hNF-L;NF-L(+/-)) of endogenous mouse NF-L proteins. Doxycycline treatment caused the rapid disappearance of human NF-L (hNF-L) mRNA in tTA;hNF-L mice, but the hNF-L proteins remained with a half-life of 3 weeks in the brain. In the sciat...

Preneoplastic and neoplastic lesions in rodent liver show alterations in the expression of various enzymes which can be used for their identification. To address the question whether these enzymatic alterations result from specific changes in the levels of hepatocyte-enriched nuclear factors (HNF), we analysed the mRNA levels of six different HNFs (HNF-1alpha, beta, HNF-3alpha, beta, gamma, and...

The HNF-4 orphan receptor is a member of the nuclear receptor family of transcription factors and a major regulator of genes involved in carbohydrate and lipid metabolism. As an initial step in characterizing the role of HNF-4 in the regulation of metabolism, we have generated a dominant negative form of HNF-4 (DN-HNF-4) that contains a defective DNA-binding domain. In gel mobility shift assays...

Hepatocyte nuclear factors 3 (HNF-3) belong to an evolutionarily conserved family of transcription factors that are critical for diverse biological processes such as development, differentiation, and metabolism. To study the physiological role of HNF-3alpha, we generated mice that lack HNF-3alpha by homologous recombination in embryonic stem cells. Mice homozygous for a null mutation in the HNF...

Hepatocyte nuclear factor-3 (HNF-3) belongs to a large family of forkhead transcription factors and is made up of three members (HNF-3alpha, -3beta and -3gamma). It has been shown that HNF-3 regulates a number of metabolically important genes. However, the mechanisms underlying this regulation of HNF-3 activity by hormones and nutrition have not yet been well elucidated. In attempting to explor...