Type 1 diabetes (T1D) is a T cell mediated autoimmune disease. During the pathogenesis, patients become progressively more insulinopenic as insulin production is lost, presumably this results from the destruction of pancreatic beta cells by T cells. Understanding the mechanisms of beta cell death during the development of T1D will provide insights to generate an effective cure for this disease....

drawbacks, such as increasing the dosage, the administration frequency and the resultant occurrence of side effects. Furthermore, as the rate-limiting step in the absorption process for poorly water-soluble drugs is the dissolution rate of such drugs in the gastrointestinal fluids rather than the rapidity of their diffusion across the gut wall, it is important to improve the oral bioavailabilit...

A new POM-based hybrid, [δ-H4PMoVMoVI11O40](L)5·5H2O (L = 4-methylpyridine-4-yl-1,8-naphthalene dicarboxylamide), was synthesized under hydrothermal conditions and characterized by IR spectroscopy, powder X-ray diffraction, photoelectron spectroscopy. This hybrid can acts as multifunctional fluorescent sensor to detect metal cation (Fe3+), anions (Cr2O72– CrO42–), antibiotics (NFT nitrofurantoi...

BACKGROUND Self-monitoring of blood glucose (SMBG) in noninsulin-treated type 2 diabetes patients (T2DM) is a controversial topic. We aimed to describe the SMBG prevalence in noninsulin-treated (NIT) T2DM patients in the Valencia Community (VC) and to analyze factors associated with their use. METHOD Cross-sectional study with 573 NIT-T2DM patients from 83 primary care surgeries. Electronic m...

Twelve strains of Fusarium moniliforme were examined for their ability to sector spontaneously on toxic chlorate medium. All strains sectored frequently; 91% of over 1200 colonies examined formed chlorate-resistant, mutant sectors. Most of these mutants had lesions in the nitrate reduction pathway and were unable to utilize nitrate (nit mutants). nit mutations occurred in seven loci: a structur...

OBJECTIVE To compare in-vitro antimicrobial susceptibility of nitrofurantoin against commonly used antimicrobials for the treatment of urinary tract infection caused by enterococci. METHODS A total of 144 enterococci (Enterococcus faecalis, n=130, Enterococcus faecium, n=14) isolated and confirmed by biochemical tests at the department of Microbiology, Armed Forces Institute of Pathology, Raw...

The issue of land use and land-use intensity has long been linked to water quality globally. Changing in New Zealand, especially pastoral systems, over the last 50 years have caused nit...

The consensus of economic experts is that income-tested programs are more efficient than non-income-tested tax-transfer programs. Most widely favored as a policy proposal is the negative income tax, (NIT) an income-tested program. This view apparently stems from the widespt:ead use of the· target efficiency measure--a conceptually flawed measure of technical rather than economic efficiency. In ...