PURPOSE Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent protein (GFP) transgenic mice (obtained at postnatal days [P]0, P5, or P60), as...

Aim of this study was to examine synaptic connectivity changes in the retina and the location and rate of apoptosis in transgenic S334ter line-3 and line-5 rats with photoreceptor degeneration. Heterozygous S334ter-line-3 and line-5 at P11-13, P30, P60, P90 and several control non-dystrophic rats (Long Evans and Sprague-Dawley) at P60, were studied anatomically by immunohistochemistry for vario...

We hypothesized that the type of wood, in combination with grit size sandpapers, would affect sanding efficiency. Fixed factors were used experiment (a belt sander pressure p = 3828 Pa, and a speed vs 14.5 m/s) as well variable (three sand belts (P60, P120, P180), six hardwood species (beech, oak, ash, hornbeam, alder, walnut) three softwood (pine, spruce, larch)). The masses test samples measu...

Objectives The aim of this study was to evaluate the clinical performance of a packable and a low shrinkage methacrylate-based composite after one year. Materials and Methods In this clinical trial, 50 class I or II restorations were placed in 25 patients. Each patient received two restorations. The tested materials were: (I) Filtek P60 + Single Bond 2 and (II) Kalore GC + Single Bond 2. The ...

Protein phosphatase 4 catalytic subunit (PP4c) is a PP2A-related protein serine/threonine phosphatase with important functions in a variety of cellular processes, including microtubule (MT) growth/organization, apoptosis, and tumor necrosis factor signaling. In this study, we report that NDEL1 is a substrate of PP4c, and PP4c selectively dephosphorylates NDEL1 at Cdk1 sites. We also demonstrate...

BACKGROUND Recent studies have highlighted the heterogeneity of gliomas and demonstrated that molecular and genetic analysis could help in their classification and in the design of treatment protocols. In a previous study we have identified a 4-gene signature highly correlated with survival of glioma patients. The aim of this study is to confirm and extend these findings by investigating the ex...