Nigella sativa (N. sativa) (Family Ranunculaceae) have been used for thousands of years as a curative remedy for various disorders. N. sativa seed reveal a broad spectrum of pharmacological activities including immunopotentiation and antihistaminic, antidiabetic, anti-hypertensive, anti-inflammatory, and antimicrobial activities. It is known as a source of thymoquinone, thymohydroquinone, dithy...

An HPLC method was developed for the simultaneous determination of nine compounds of Nigella sativa L. The separation was achieved within 23 min by using C18 column material, a water-acetonitrile mobile phase, both containing 0.1% acetic acid gradient system and a temperature of 35 degrees C. The method was validated for linearity, repeatability, LOD, and LOQ. The LOD and LOQ of nine compounds ...

A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was...

The medicinal plants have attracted great attention in the recent years for better therapeutic management of diseases. Nigella sativa is one of the most extensively studied plants and has gained more and more interest for potential medical use in recent years. Historical and traditional uses of this herb have been widely documented in ancient documents; and Nigella sativa have been broadly used...

The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxi...

BACKGROUND Several compounds obtained from plants have potential insecticidal, growth deterrent or repellent characteristics. The control of hard ticks by non-chemical substances was targeted in this study. METHODS The effect of 36 materials on in-vitro ticks was studied, including 2 absolute controls (water only or absolute ethyl alcohol only), 6 conventionally used spinosad preparations (aq...

Most of the bacterial pathogens are resistant to existing synthetic antibacterial agents demanding an increasing effort to seek effective phytochemicals as antibacterial agents against such pathogens. Nigella sativa L. (black cumin) seeds play an important role in folk medicine and some of its major constituents are reported to be pharmacologically active. In this present work, black cumin seed...

Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and gluta...

background and aim: in most infections and diseases, to cure and decrease the effect of disease, induction and increasing power of immuno system are necessary. nigella sativa is a plant that has been used for treatment of many diseases. in this survey, the effect of nigella sativa is surveyed in strengthening of monocyte phagocytosis so that the use and mechanism of this plant for strengthening...