We analyzed an Escherichia coli strain which harbours a chromosomal mutation that blocks the hemolysin excretion. Compartmentation studies showed that hemolysin accumulates in the cytoplasm and not in the periplasm. The mutation did not affect the SDS-PAGE protein pattern of the outer membrane, although some alterations were apparent in the periplasmic protein pattern. The mutant strain, E. col...

Consistent performance of anti-drug antibody (ADA) assays through all stages of clinical development is critical for the assessment of immunogenicity and interpretation of PK, PD, safety, and efficacy. The electrochemiluminescent assays commonly employed for ADA measurement use drug conjugated with ruthenium and biotin to bind ADA in samples. Here we report an association between high nonspecif...

Poverty-Related Diseases (PRDs) emphasize poverty as a 'breeding-ground' for a range of diseases. The study presented here starts from the premise that poverty is a general condition that can limit people's capacity to prevent, mitigate or treat diseases. Using an interpretation of health seeking behaviour (HSB), inspired by the salutogenic approach, we investigated how people deal with PRDs, t...

Although obesity is well established in hamsters, studies using diets with high levels of simple carbohydrate associated with lipids are necessary to assess the impact of this type of food in the body. In this study a high sugar and butter diet (HSB) and high temperature were employed towards this end. Obesity was successfully induced at a temperature of 30.3°C to 30.9°C after 38 days feeding t...

The atmospheric transmittance model for AMSU and HSB channels on the Aqua spacecraft uses a polynomial approximation to the temperature dependence of oxygen-band opacity within atmospheric layers. It uses look-up tables to calculate local water-vapor line intensity and pressure-broadening parameters as well as contributions to absorption from the water-vapor continuum, distant lines, and cloud ...

We investigate whether a correlation exists between the concentration (2̧00) and spin (λ) parameters of dark matter haloes forming in ΛCDM N-body simulations. In particular, we focus on haloes with virial masses in the range 10 6 Mvir/h M⊙ 6 2×10 , characteristic of the hosts of Low Surface Brightness (LSB) and High Surface Brightness (HSB) galaxies. Our analysis demonstrates that 2̧00 and λ are ...

Using the IRAM 30m telescope we have obtained seven new, deep CO J(1−0) and J(2−1) observations of low surface brightness (LSB) galaxies. Five of the galaxies have no CO detected to extremely low limits (0.1 – 0.4 K km s−1 at J(1−0)), while two of the galaxies, UGC 01922 and UGC 12289, have clear detections in both line transitions. When these observations are combined with all previous CO obse...

BACKGROUND This was a post hoc analysis of patients with non-squamous histology from a phase III maintenance pemetrexed study in advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS The six symptom items' [average symptom burden index (ASBI)] mean at baseline was calculated using the lung cancer symptom scale (LCSS). Low and high symptom burden (LSB, ASBI < 25; HSB, ASBI ≥ 25) an...